In spite of their low affinity for binding to their antigen, IgM antibodies can be quite effective at promoting the elimination of extracellular bacterial infections. This is due to: The ability of IgM antibodies to traffic across epithelial surfaces Multivalent binding of IgM pentamers to repetitive epitopes on bacterial surfaces The high concentration of IgM antibodies in the serum and in all tissues The early production of IgM antibodies during an immune response The high rate of somatic hypermutation in the genes encoding IgM antibodies
In spite of their low affinity for binding to their antigen, IgM antibodies can be quite effective at promoting the elimination of extracellular bacterial infections. This is due to: The ability of IgM antibodies to traffic across epithelial surfaces Multivalent binding of IgM pentamers to repetitive epitopes on bacterial surfaces The high concentration of IgM antibodies in the serum and in all tissues The early production of IgM antibodies during an immune response The high rate of somatic hypermutation in the genes encoding IgM antibodies
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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In spite of their low affinity for binding to their antigen, IgM antibodies can be quite effective at promoting the elimination of extracellular bacterial infections. This is due to:
- The ability of IgM antibodies to traffic across epithelial surfaces
- Multivalent binding of IgM pentamers to repetitive epitopes on bacterial surfaces
- The high concentration of IgM antibodies in the serum and in all tissues
- The early production of IgM antibodies during an immune response
- The high rate of somatic hypermutation in the genes encoding IgM antibodies
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