In sickle-cell disease, as a result of a single amino acid change, the mutant hemoglobin tetramers associate with each other and assemble into large fibers. Based on this information alone, what does the sickle-cell hemoglobin exhibit? A) only altered primary structure B) only altered tertiary structure C) only altered quaternary structure D) altered primary structure and altered quaternary structure; the secondary and tertiary structures may or may not be altered

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