Sickle cell anemia is a horrific molecular disease that causes a multitude of issues within the human body, despite the disease’s hemoglobin only slightly varying in structure, as normal hemoglobin’s glutamic acid is instead replaced with valine in the beta-globin amino acid chain. By only changing structurally in this slight amount , sickle cell takes on its unique shape which then causes a multitude of issues within the human body. How does the replacement of glutamic acid with valine end up resulting in this shape, and how would it affect its interaction with the rest of the body?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Sickle cell anemia is a horrific molecular disease that causes a multitude of issues within the human body, despite the disease’s hemoglobin only slightly varying in structure, as normal hemoglobin’s glutamic acid is instead replaced with valine in the beta-globin amino acid chain. By only changing structurally in this slight amount , sickle cell takes on its unique shape which then causes a multitude of issues within the human body. How does the replacement of glutamic acid with valine end up resulting in this shape, and how would it affect its interaction with the rest of the body? 

 
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Mutations are notorious to cause many horrifying diseases in humans . They can decrease the quality of life and can effect the offsprings as well in this case the mutation is a single base pair mutation which alters just one amino acid leading to altered shape 

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