4. Which of the following mutations would most likely keep the transitions of T state to R state in hemoglobin unchanged, or similar to the transitions that occur in the native molecule? The three-letter codes for amino acids are used, and the numbers following the amino acids designate the amino acid position in the protein. By convention, the original, native amino acid is listed first, followed by the mutational change. (a) Tyr 42 to Phe 42 O (b) Tyr 42 to Gly 42 (c) Asp 94 to Glu 94 O (d) Asp 94 to lle 94
4. Which of the following mutations would most likely keep the transitions of T state to R state in hemoglobin unchanged, or similar to the transitions that occur in the native molecule? The three-letter codes for amino acids are used, and the numbers following the amino acids designate the amino acid position in the protein. By convention, the original, native amino acid is listed first, followed by the mutational change. (a) Tyr 42 to Phe 42 O (b) Tyr 42 to Gly 42 (c) Asp 94 to Glu 94 O (d) Asp 94 to lle 94
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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4)

Transcribed Image Text:**Question 4: Hemoglobin Mutation and Conformational Stability**
Which of the following mutations would most likely keep the transitions of T state to R state in hemoglobin unchanged, or similar to the transitions that occur in the native molecule? The three-letter codes for amino acids are used, and the numbers following the amino acids designate the amino acid position in the protein. By convention, the original, native amino acid is listed first, followed by the mutational change.
Options:
- (a) Tyr 42 to Phe 42
- (b) Tyr 42 to Gly 42
- (c) Asp 94 to Glu 94
- (d) Asp 94 to Ile 94
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