How does sickle cell hemoglobin differ from normal hemoglobin at the fourth level of protein structure (the sum of all the folded protein chains)?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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 How does sickle cell hemoglobin differ from normal hemoglobin at the fourth level of protein structure (the sum of all the folded protein chains)?

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Quaternary structure of a protein is defined as the association and arrangement of all the multiple folded subunits in a multi-subunit complex form. All the subunits in the complex are held together by hydrogen bonds and the nonpolar side chains are held by van der Waals force.

The quaternary structure of proteins are called as oligomeric proteins and they play a major role in many biological processes(metabolism, replication, signal transduction etc). 

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