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In Figure 8-15, what do you think would be the effect of a A to G mutation in the branch point residue of the intron? (Two answers.) The U5 snRNP would bind to the A that is now the first residue of the intron, and splicing would proceed normally. The U1 snRNP would be unable to bind to the intron, which would prevent intron splicing from occurring. The U1 snRNP would might find a nearby GU and use that for splicing, which would allow splicing to occur but would have consequences on translation. The U2 snRNP would be unable to bind to the branch point, which would prevent intron splicing from occurring. The U2 snRNP might find another nearby A and use that for the branch point, which might allow normal intron splicing. The hydroxyl from the branch point A would be unable to complete its transesterification reaction, and intron splicing would come to a halt.

In Figure 8-15, what do you think would be the effect of a A to G mutation in the branch point residue of the intron? (Two answers.) The U5 snRNP would bind to the A that is now the first residue of the intron, and splicing would proceed normally. The U1 snRNP would be unable to bind to the intron, which would prevent intron splicing from occurring. The U1 snRNP would might find a nearby GU and use that for splicing, which would allow splicing to occur but would have consequences on translation. The U2 snRNP would be unable to bind to the branch point, which would prevent intron splicing from occurring. The U2 snRNP might find another nearby A and use that for the branch point, which might allow normal intron splicing. The hydroxyl from the branch point A would be unable to complete its transesterification reaction, and intron splicing would come to a halt.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Pre-MRNA A/C A G GU AG A GU CU A/G A C/U NC AG G Frequency of occurrence (%) 70 60 80 100 100 95 70 80 45 80 90 80 100 80 80 100 100 60 15-45 bases In Figure 8-15, what do you think would be the effect of a A to G mutation in the branch point residue of the intron? (Two answers.) The U5 snRNP would bind to the A that is now the first residue of the intron, and splicing would proceed normally. The U1 snRNP would be unable to bind to the intron, which would prevent intron splicing from occurring. The U1 snRNP would might find a nearby GU and use that for splicing, which would allow splicing to occur but would have consequences on translation. The U2 snRNP would be unable to bind to the branch point, which would prevent intron splicing from occurring. The U2 snRNP might find another nearby A and use that for the branch point, which might allow normal intron splicing. The hydroxyl from the branch point A would be unable to complete its transesterification reaction, and intron splicing would come to a halt.
Transcribed Image Text:Pre-MRNA A/C A G GU AG A GU CU A/G A C/U NC AG G Frequency of occurrence (%) 70 60 80 100 100 95 70 80 45 80 90 80 100 80 80 100 100 60 15-45 bases In Figure 8-15, what do you think would be the effect of a A to G mutation in the branch point residue of the intron? (Two answers.) The U5 snRNP would bind to the A that is now the first residue of the intron, and splicing would proceed normally. The U1 snRNP would be unable to bind to the intron, which would prevent intron splicing from occurring. The U1 snRNP would might find a nearby GU and use that for splicing, which would allow splicing to occur but would have consequences on translation. The U2 snRNP would be unable to bind to the branch point, which would prevent intron splicing from occurring. The U2 snRNP might find another nearby A and use that for the branch point, which might allow normal intron splicing. The hydroxyl from the branch point A would be unable to complete its transesterification reaction, and intron splicing would come to a halt.
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