i 2. Predict and explain the effect on GAL1 transcription, in the presence of galactose alone, of the following mutations (image from book pasted for your convenience): a. Deletion of one Gal4-binding site in the GAL1 UAS element. b. Deletion of all four Gal4-binding sites in the GAL1 UAS element. c. Deletion of the Mig1-binding site upstream of GAL1. Deletion of the Gal4 transactivation domain. d. e. Deletion of the GAL80 gene. f. Deletion of the GAL1 promoter. g. Deletion of the GAL3 gene. (a) (b) Glucose Galactose Gal3p Glucose Galactose Glucose Galactose (c) + UAS GAL Figure 21-10 Molecular Biology: Principles and Practice, Second Edition 2015 Macmillan Education Gal80p -Gal4p Mig1- binding site -ATP -ATP Tup1 Mig1 OFF (basal) GAL ON GAL OFF GAL

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Gene Interactions

When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.

Gene Expression

Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.