Answered: HN HO. OH 오- СОН -F Atorvastatin; the…

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Biochemistry

HN HO. OH 오- СОН -F Atorvastatin; the benzene ring on the left is hydroxylated.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter10: From Proteins To Phenotypes

Section: Chapter Questions

Problem 14QP: If phenylalanine was not an essential amino acid, would diet therapy (the elimination of...

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Question

What is a step-by-step mechanism of the formation of the epoxy intermediate, starting with the Cyctochrome P450 high valent iron-oxo intermediate as your oxidant

The drug Atorvastatin (brand name is Lipitor, used to lower cholesterol levels) is
shown below. This molecule is rapidly metabolized (t = 14 hours) by Cytochrome P450
to a para-hydroxy derivative of the benzene ring attached to the amide group (this is
followed by reaction of the acid group with glucose and excretion via bile). The
Cytochrome P450-catalyzed metabolic process occurs via an epoxide intermediate.

HN
HO.
OH
오-
СОН
-F
Atorvastatin; the benzene ring on the left is
hydroxylated.

Chemical pathways by which living things function, especially those that provide cellular energy, such as the transformation of energy from food into the energy of ATP. Metabolism also focuses on chemical pathways involving the synthesis of new biomolecules and the elimination of waste.

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