he family is shown in both pedigrees below. Each pedigree focuses on a different monogenic, fully enetrant phenotype. d individuals affected by Phenotype 1: d individuals affected by Phenotype 2: Phenotype 1: Which modes of inheritance can be ruled out, base don't this pedigree? For each mode of inheritance listed below, either state that it is not ruled out, or describe a detail of the pedigree that allows you to rule it out. Autosomal recessive Autosomal dominant X-linked recessive X-linked dominant Y-linked Phenotype 2: Which modes of inheritance can be ruled out, base don't this pedigree? For each mode of inheritance listed below, either state that it is not ruled out, or describe a detail of the pedigree that allows you to rule it out. Autosomal recessive Autosomal dominant

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**Pedigree Analysis: Understanding Inheritance Patterns**

This educational exercise examines a single family represented in two separate pedigrees, each highlighting a distinct monogenic, fully penetrant phenotype. The analysis focuses on determining possible modes of inheritance by evaluating the patterns of affected individuals in each pedigree.

**Pedigree Details**

- **Shaded individuals** are those affected by the phenotype being analyzed.

**Pedigree Analysis for Phenotype 1:**

1. **Diagram Explanation:**
   - The pedigree chart shows three generations.
   - Affected individuals are shaded, while unaffected individuals are not.
   - Key elements to observe include sex-linked or autosomal inheritance possibilities, and whether the trait is dominant or recessive.

2. **Problem Solving Question:**
   a. **Phenotype 1**: Assess which modes of inheritance can be ruled out based on the pedigree. For each mode of inheritance listed below, either confirm that it is not ruled out or explain a distinct feature of the pedigree that allows its exclusion:
      - Autosomal recessive
      - Autosomal dominant
      - X-linked recessive
      - X-linked dominant
      - Y-linked

**Pedigree Analysis for Phenotype 2:**

1. **Diagram Explanation:**
   - Similar structure as Phenotype 1 with three generations.
   - Shaded individuals indicate those affected differently than in Phenotype 1.
   - Observations include whether inheritance differs from autosomal due to sex-linked traits.

2. **Problem Solving Question:**
   b. **Phenotype 2**: Determine which modes of inheritance can be ruled out based on the pedigree. For each mode of inheritance listed below, confirm whether it is excluded, or describe specifics of the pedigree that lead to exclusion:
      - Autosomal recessive
      - Autosomal dominant
      - X-linked recessive
      - X-linked dominant

This exercise is designed to deepen understanding of genetic inheritance patterns through critical analysis of pedigree charts. In a classroom setting, students should discuss potential inheritance scenarios and support their conclusions with evidence from the charts.
Transcribed Image Text:**Pedigree Analysis: Understanding Inheritance Patterns** This educational exercise examines a single family represented in two separate pedigrees, each highlighting a distinct monogenic, fully penetrant phenotype. The analysis focuses on determining possible modes of inheritance by evaluating the patterns of affected individuals in each pedigree. **Pedigree Details** - **Shaded individuals** are those affected by the phenotype being analyzed. **Pedigree Analysis for Phenotype 1:** 1. **Diagram Explanation:** - The pedigree chart shows three generations. - Affected individuals are shaded, while unaffected individuals are not. - Key elements to observe include sex-linked or autosomal inheritance possibilities, and whether the trait is dominant or recessive. 2. **Problem Solving Question:** a. **Phenotype 1**: Assess which modes of inheritance can be ruled out based on the pedigree. For each mode of inheritance listed below, either confirm that it is not ruled out or explain a distinct feature of the pedigree that allows its exclusion: - Autosomal recessive - Autosomal dominant - X-linked recessive - X-linked dominant - Y-linked **Pedigree Analysis for Phenotype 2:** 1. **Diagram Explanation:** - Similar structure as Phenotype 1 with three generations. - Shaded individuals indicate those affected differently than in Phenotype 1. - Observations include whether inheritance differs from autosomal due to sex-linked traits. 2. **Problem Solving Question:** b. **Phenotype 2**: Determine which modes of inheritance can be ruled out based on the pedigree. For each mode of inheritance listed below, confirm whether it is excluded, or describe specifics of the pedigree that lead to exclusion: - Autosomal recessive - Autosomal dominant - X-linked recessive - X-linked dominant This exercise is designed to deepen understanding of genetic inheritance patterns through critical analysis of pedigree charts. In a classroom setting, students should discuss potential inheritance scenarios and support their conclusions with evidence from the charts.
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