1. The pedigree chart in Figure 5.29 shows the inheritance of haemopiu family. Study the pattern of inheritance in the pedigree chart, and then answer the questions that follow. о 5 6. 3 8 9 10 11 Key Unaffected male Haemophiliac male О Unaffected female Fig. 5.29 Pedigree chart of a family affected by haemophilia a) What is the genotype and phenotype of individuals 2 and 4? b) (i) How many of the unaffected family members are definitely carriers of the recessive allele? (ii) How are you able to tell which of the family members are carriers? (4) (1) (3) c) (i) If Individual 11 marries a carrier female, what percentage of their sons is likely to be haemophiliacs? (1) (ii) Use a genetic diagram to show how you worked out your answer in i, (6) 2. Why is haemophilia never passed from father to son, even though it is most common in males? (4) 3. Can a mother pass on a sex-linked gene to her daughter? (1) 4. Sipho has red-green colour blindness. One of his grandfathers was also. colour blind. Explain whether it was his mother's father or father's father who had this sex-linked recessive trait. (4)

1. The pedigree chart in Figure 5.29 shows the inheritance of haemopiu family. Study the pattern of inheritance in the pedigree chart, and then answer the questions that follow. о 5 6. 3 8 9 10 11 Key Unaffected male Haemophiliac male О Unaffected female Fig. 5.29 Pedigree chart of a family affected by haemophilia a) What is the genotype and phenotype of individuals 2 and 4? b) (i) How many of the unaffected family members are definitely carriers of the recessive allele? (ii) How are you able to tell which of the family members are carriers? (4) (1) (3) c) (i) If Individual 11 marries a carrier female, what percentage of their sons is likely to be haemophiliacs? (1) (ii) Use a genetic diagram to show how you worked out your answer in i, (6) 2. Why is haemophilia never passed from father to son, even though it is most common in males? (4) 3. Can a mother pass on a sex-linked gene to her daughter? (1) 4. Sipho has red-green colour blindness. One of his grandfathers was also. colour blind. Explain whether it was his mother's father or father's father who had this sex-linked recessive trait. (4)

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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O. 2 Hemophilia A is an X-linked trait where blood clotting is affected due to a mutation in a clotting factor protein. Georgio has hemophilia and attends a support group where he meets Gbenga, who does not have the disease, but whose father has hemophilia. Her mother is not affected. A) If they marry, what percentage % of all their children will have hemophilia? % B) Georgio meets another woman, Maria, at the hemophilia support group. Maria also lacks the trait, but her mother has hemophilia while her father is unaffected. # 3 Would a Georgio-Maria mating provide a larger chance of having afflicted children compared to a Georgio-Gbenga mating? C) Show how you came up with your answer to B. Edit View Insert Format Tools Table 12pt ✓ 80 F3 V Paragraph ✓ $ 4 Yes or No 000 000 F4 DO LO % 5 BIUAV T² | F5 ^ MacBook Air 6 2 F6 V & 7 F7 * 8 DII F8 ( 9 DD F9 1 0 S F
2. Hemophilia is an X linked recessive trait. There is a woman who is a carrier for hemophilia and marries a man with hemophilia. a) Complete the Punnett Square (it is a google drawing so you will have to double click it to go to the drawing and type in and around the square. Hold the CONTROL (or Command) button and press the PERIOD button to write a superscript/exponent.) b) What are the possible genotypes of the children? c) Could any of their children have hemophilia? If so, would the child be male or female? Explain your reasoning.
What is the most likely inheritance pattern shown in image B, below? B A E KEY Homozygous Homozygous Heterozygous Heterozygous Wild Type Male Female Male Female Male Note: Completely red symbol denotes an individual exhibiting the phenotype of interest CI 11 III IV V 1/4 A Autosomal Dominant Autosomal Recessive Sex-linked Dominant Sex-Linked Recessive Mitochondrial 1/2 1/2 1/2 1/2 Wild Type Female 1/4 1/2 B Affected Known carrier Affected female Normal female Affected male Normal male
Hyperphosphatemic familial tumoral calcinosis (HFTC) is a condition characterized by an increase in the levels of phosphate in the blood (hyperphosphatemia) and abnormal deposits of phosphate and calcium (calcinosis) in the body's tissues. Research has described many causes for the condition that results in different patterns of inheritance. Here is what we know of the family members: (no other information is provided) II II IV V VI A) Based on the information presented, what is the most likely mode of inheritance? In your own words, explain your reasoning. B) What are the chances that V-6 and V-7 have an afflicted child? C) What are the chances that VI-9 and VI-10 have a HFTC afflicted child?
The pedigree chart below indicates that individual I12 has cystic fibrosis. What is the chance that I13 is a carrier of the cystic fibrosis allele? Please explain how you determined this. I 1 II 1| 2 3 4 5 6 7 III 1 2 3 4 5 6 7 8 9
Explain why familial breast cancer shows a dominant pattern of inheritance in a pedigree even though it is recessive at the cellular level.
Below is a pedigree chart for a family that has a history of Alkaptonuria. Individuals infected with this condition can have darkened skin, brown urine, and can suffer from joint damage and other complications. Given this pedigree answer the following questions. Given the data in the pedigree chart is this genetic condition autosomal dominant or autosomal recessive? What are the genotypes for #1, #2, and #3? If either of the 4th generation "aa" females were to mate with a homozygous dominant male would any of their offspring illustrate the phenotype? Why or why not?
The given pedigree chart corresponds with generational cystic fibrosis. If individuals III-2 and III-3 were to have a second child, what is the probability that their second child will have cystic fibrosis?
1. In humans, hemophilia is a sex linked trait. Females can be normal, carriers, or have the disease. Males will have the disease or not (but they won't be ever carriers) XH XH = female, normal XH Xh = female, carrier Xh Xh = female, hemophilic XH Y = male, normal Xh Y = male, hemophilic a) Show the cross of a man who has hemophilia with a woman who is a carrier. b) What is the probability that their children have the disease
y 301 Amelogenesis imperfecta is X-linked dominant. Affected XY individuals have extremely thin enamel on the teeth while XX carriers have grooved teeth from uneven deposition of enamel. If an unaffected XY individual were to produce children with a XX carrier partner, a. what would be the expected chance of a XY child being affected with the disease? b. what would be the expected chance of a XY child being affected with the disease?
1. A pure breeding dark blue flowered plant is crossed with a pure breeding white flowered plant and all the F1 progeny are dark blue flowered. Identify the type of inheritance (complete dominance and if so which trait is dominant; or incomplete dominance or codominance/multiple alleles or sex linked, circle one) and define your symbols_________________________________________ a) What is the genotype of the F1 generation? _______________________ What is the result of F1 x F1 cross? b) What is the genotypic ratio of the above cross (Write number next to genotype)? ___________________________________________________________________ c) What is the phenotypic ratio of the above cross? (Write number next to phenotype)? ___________________________________________________________________
Finally, draw out a Punnett square to help you consider the cross between these possible gametes. Sex-Linked1 := Homework • Unanswered What are the possible genotypes of the offspring shown in your Punnett square? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. XBxb and xbY a b XBXB and xbY Neither of these answers is correct Unanswered • 1 attempt left Submit Sex-Linked2 Homework • Unanswered What are the possible phenotypes of the offspring? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a Females with normal color vision and males who are colorblind Females who are colorblind and males who have normal color vision