Draw the amino acid–Schiff base that forms in the breakdown of 3-hydroxykynurenine to yield 3-hydroxyanthranilate in the tryptophan degradation pathway (Fig.) and indicate which bond is to be cleaved. HHHHC00C-CH2H,0C-Coo--CH-C-CO0--CH-C-CO0NHNHNHNH2HHTryptophanN-FormylkynurenineКупurenineOg + NADPHH,0 + NADP+HH20H-CH,-C-CO0-H;C-C-Co0-NHNH2NH2NHOHонAlanine3-HydroxyanthranilateS-Hydroxykynurenine5 reactions7 reactionsCH3-C-CH2-C00 +-O.CoCO2a-KetoadipateAcetoacetate

In enzymology, Kynurenine-3-monooxygenase also known as Kynurenine hydroxylase is an enzyme that…

Answered: H H H HC00 C-CH2 H,0 C-Coo- -CH-C-CO0-…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Draw the amino acid–Schiff base that forms in the breakdown of 3-hydroxykynurenine to yield 3-hydroxyanthranilate in the tryptophan degradation pathway (Fig.) and indicate which bond is to be cleaved.

H
H
H
HC00
C-CH2
H,0
C-Coo-
-CH-C-CO0-
-CH-C-CO0
NH
NH
NH
NH2
H
H
Tryptophan
N-Formylkynurenine
Купurenine
Og + NADPH
H,0 + NADP+
H
H20
H
-CH,-C-CO0-
H;C-C-Co0-
NH
NH2
NH2
NH
OH
он
Alanine
3-Hydroxyanthranilate
S-Hydroxykynurenine
5 reactions
7 reactions
CH3-C-CH2-C00 +-
O.
Co
CO2
a-Ketoadipate
Acetoacetate

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