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Explain why Mismatch Repair of absolutely requires semi-conservative DNA replication during S phase

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter28: Dna Metabolism: Replication, Recombination, And Repair

Section: Chapter Questions

Problem 22P

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Concept explainers

Tissue regeneration & repair

Tissue regeneration involves the restoration of tissue components by regrowth of damaged tissues. In contrast, tissue repair involves patching of injured tissue rather than restoring it. It is the proliferative capacity of the cells that decides the amount of regeneration against the repair that would occur in the tissue. Both regeneration and repair depending on the duration of the injury and response to the inflammation.

Question

Explain why Mismatch Repair of absolutely requires semi-conservative DNA replication during S phase.

Definition Definition Mechanism by which deoxyribonucleic acid (DNA) is capable of producing an exact copy of itself. DNA molecules utilize a semiconservative method for replication. DNA replication is the most essential part of biological inheritance and is crucial for cell division during growth and repair of damaged tissues.

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Describe the structure and location of a D-loop.
For S phase to be completed in a timely manner, DNA replication must be initiated from multiple origins in eukaryotes. In S. cerevisiae, what role do S phase CDKs and DDKs play to ensure that the entire genome is replicated once and only once per cell cycle?
Explain why base excision repair, nucleotide excision repair, and mismatch repair—which all require nucleases to excise damaged DNA—require DNA ligase.
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2b) Suppose you generated a mutant E. coli strain in which it was DNA Polymerase I that was inactivated - assuming that all the other enzymes involved in replication remained fully functional, how would DNA replication in these mutant cells lacking DNA Pol I differ from DNA replication in normal E. coli? Briefly explain why you would expect to see that change/those changes in DNA replication in the mutant cells.
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Match the DNA repair mechanism to the type of repair it fixes. Base excision repair DNA polymerase proofreading Non-homolgous end-joining Mismatch repair Nucleotide excision repair Double strand breaks Mismatches in S-phase Mismatches after S-phase, before M-phase Mismatches in interphase Thymidine Dimer Double strand breaks Mismatches in S-phase Mismatches after S-phase, before…
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