Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 11, Problem 18QP
Replication involves a period of time during which DNA is particularly susceptible to the introduction of mutations. If
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Why is the replication of DNA referred to as a semiconservative process? What is the experimental evidence for the semiconservative nature of the process? What experimental results would you expect if replication of DNA were a conservative process?
In DNA replication, the role of topoisomerase is to
Question 11 options:
a)
"unzip" the double stranded DNA in front of DNA polymerase.
b)
maintain the single stranded DNA.
c)
supercoil the DNA after the replication fork has passed.
d)
relieve supercoil tension in the DNA in front of the replication fork.
What mechanism was originally proposed as one of the three models for
DNA replication? What is the name given to the short stretches of DNA
formed on the lagging strand? How can these short fragments be initiated?
Chapter 11 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 11.4 - Consumer products including bandages, cotton...Ch. 11.4 - Prob. 2EGCh. 11 - Prob. 1CSCh. 11 - Prob. 2CSCh. 11 - Prob. 3CSCh. 11 - Prob. 1QPCh. 11 - Achondroplasia is an autosomal dominant form of...Ch. 11 - Why is it almost impossible to directly measure...Ch. 11 - What are the factors that influence the mutation...Ch. 11 - Achondroplasia is a rare dominant autosomal defect...
Ch. 11 - Although it is well known that X-rays cause...Ch. 11 - Prob. 7QPCh. 11 - Bruce Ames and his colleagues have pointed out...Ch. 11 - Define and compare the following types of...Ch. 11 - If the coding region of a gene (the exons)...Ch. 11 - Two types of mutations discussed in this chapter...Ch. 11 - Prob. 12QPCh. 11 - A frameshift mutation is caused by a: a....Ch. 11 - In the gene-coding sequence shown here, which of...Ch. 11 - Prob. 15QPCh. 11 - Familial retinoblastoma, a rare autosomal dominant...Ch. 11 - Tay-Sachs disease is an autosomal recessive...Ch. 11 - Replication involves a period of time during which...Ch. 11 - Our bodies are not defenseless against mutagens...Ch. 11 - The cystic fibrosis gene encodes a chloride...
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- Why is DNA replication is considered a semi-discontinuous process? Explain in detail.arrow_forwardIf the sequence of one single strand of DNA is C-A-A-G-T-A-G-G-C-T, what is the sequence of the complementary strand? Describe the origin of each strand of the new double helices created after DNA replication. Why is DNA replication important to the growth and development of a multicellular organism? Place the following terms in the correct order from smallest to largest: Nucleosome, supercoils, coils, chromosome, DNA double helixarrow_forwardIn DNA replication, there are leading and lagging strands because A) DNA replication is conservative and a completely new DNA molecule must be made. B) DNA replication is semiconservative and each strand is copied simultaneously in opposite directions. C) the strands of DNA are parallel and are copied in the same direction simultaneously. D) one strand of DNA is copied faster than the other.arrow_forward
- The following statements are correct EXCEPT: A) Information in the DNA is transcribed int mRNA and translated into proteins B) Information in the DNA is translated int mRNA and transcribed into proteins C) Information in the DNA is copied by DNA polymerase D) The lagging strand during DNA replication is synthesized continuously to form the okazaki fragments E) B and Darrow_forwardBelow is a diagram of DNA replication as currently believed to occur in E. coli. Arrows start from numbers and end at specific points. Answer the questions relating to the locations specified by the numbers (1) Which end (5' or 3') of the molecule is here? (2) Which enzyme is probably functioning here to deal with supercoils in the DNA? (3) Which enzyme is probably functioning here to unwind the DNA?arrow_forwardAssume a deletion occurs in a gene that encodes DNA polymerase I and no functional DNA polymerase I is produced. What will be the most likely consequence of this mutation? The DNA would not exist in a supercoiled state. There would be no RNA primers laid down. The DNA will not be able to unwind to initiate replication. The DNA strands would contain pieces of RNA. There would be no DNA replication on the leading or lagging strands.arrow_forward
- 2) Replicating structures in DNA can be observed in the electron microscope. Regions being replicated appear as bubbles. a) How many replication forks are present? b) Assuming bidirectional replication, how many origins of replication are active in this DNA molecule? c) Assuming that all replication forks move at the same speed, which origin of replication was activated first (left, middle or right)? Why?arrow_forwardInitiation of replication occurs at an "origin of replication" site that typically includes an AT-rich region. Initiation benefits from these AT-rich regions because: the AT-rich region recruits topoisomerase to begin the process of DNA replication. GC-rich regions are impossible to replicate because of their strong H-bonds. the AT-rich region recruits DNA polymerase to begin the process of DNA replication. adenine-thymine pairs are held together by two H-bonds, making them easier to separate during unwinding. None of the answers is correct.arrow_forwardIdentify two important enzymes involved in replication. Where does replication occur in the cell? What is the product of replication? Why is replication important to the cell and living organism? What is the process of copying DNA called?arrow_forward
- You are studying a colony of cells and determine that some of these cells have a mutated DNA polymerase I that results in loss of function of this enzyme. A) What will the effect of the mutation in DNA polymerase I be on DNA replication? In your answer make sure to describe what would be observed in the leading and lagging strand and explain your reasoning. B) Will this mutation in DNA polymerase I have an impact on another step in DNA replication? In your answer make sure to indicate whether DNA replication will be impacted or not. If it is not, explain why. If it is impacted, then describe the step that is impacted and name the molecule or enzyme involved.arrow_forwardAs a result of DNA replication two DNA molecules come into existence. Why is it not correct to assert that two “new” DNA molecules are created? What is the name given to the process concerning that fact?arrow_forwardWhich of the following statements is false about DNA replication? A) Each lagging strand of DNA is started by an RNA primer. B) DNA polymerase joins nucleotides in the 5' to 3' direction only. C) The leading strand of DNA is made continuously. D) More than one replication fork is present. E) A replication bubble opens in one direction only.arrow_forward
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