Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 11, Problem 17QP
Tay-Sachs disease is an autosomal recessive disease. Affected individuals do not often survive to reproductive age. Why has Tay-Sachs persisted in humans?
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Hereditary hemochromatosis is an autosomal recessive genetic disorder that causes the body to absorb too much iron from the diet. This excess iron is stored in the body's tissues and organs, particularly the skin, heart, liver, pancreas, and joints. Because humans cannot increase the excretion of iron, excess iron can overload and eventually damage tissues and organs.
Some individuals who are homozygous for this autosomal recessive gene experience only skin discoloration and joint pain, others experience heart disease in addition to the skin discoloration, still other individuals suffer also suffer from diabetes, severe heart disease, and liver damage. Name and define this genetic phenomenon and explain how it relates to this specific genetic situation described above.
Sickle-cell disease is an autosomal recessive disorder that causes the red blood cells of an affected person to be rigid and abnormally shaped. The life expectancy of a person affected by the disorder is approximately 45 years. Carriers of the disease produce some sickled cells, but not enough to be symptomatic.Malaria is a potentially fatal disease caused by the protist Plasmodium falciparum.Studies have shown that those affected by sickle-cell disease (genotype ss), as well as carriers who possess only one sickle-cell allele (Ss), are much more resistant to malaria than those with homozygous dominant genotypes (SS). This resistance is created in part by the rupturing of any sickled red blood cells that are infected with the parasite, preventing Plasmodium falciparum from reproducing and making it more susceptible to the host's immune system.Which of the following statements best predicts what would happen in response to a prolonged epidemic of malaria in a population with no previous…
To determine whether radiation associated with the atomic bombings of Hiroshima and Nagasaki produced recessive germ-line mutations, scientists examined the sex ratio of the children of the survivors of the blasts. Can you explain why an increase in germ-line mutations might be expected to alter the sex ratio?
Chapter 11 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 11.4 - Consumer products including bandages, cotton...Ch. 11.4 - Prob. 2EGCh. 11 - Prob. 1CSCh. 11 - Prob. 2CSCh. 11 - Prob. 3CSCh. 11 - Prob. 1QPCh. 11 - Achondroplasia is an autosomal dominant form of...Ch. 11 - Why is it almost impossible to directly measure...Ch. 11 - What are the factors that influence the mutation...Ch. 11 - Achondroplasia is a rare dominant autosomal defect...
Ch. 11 - Although it is well known that X-rays cause...Ch. 11 - Prob. 7QPCh. 11 - Bruce Ames and his colleagues have pointed out...Ch. 11 - Define and compare the following types of...Ch. 11 - If the coding region of a gene (the exons)...Ch. 11 - Two types of mutations discussed in this chapter...Ch. 11 - Prob. 12QPCh. 11 - A frameshift mutation is caused by a: a....Ch. 11 - In the gene-coding sequence shown here, which of...Ch. 11 - Prob. 15QPCh. 11 - Familial retinoblastoma, a rare autosomal dominant...Ch. 11 - Tay-Sachs disease is an autosomal recessive...Ch. 11 - Replication involves a period of time during which...Ch. 11 - Our bodies are not defenseless against mutagens...Ch. 11 - The cystic fibrosis gene encodes a chloride...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Why are recessive conditions more common than dominant ones? How could being a carrier of a recessive disease be beneficial?arrow_forwardHuman growth hormone (HGH) is necessary for growth during human adolescence. Pituitary dwarfism is a condition that results from the inability of a person to produce HGH. Luckily, the human gene for HGH can be inserted into E. coli bacteria, which are able to make our HGH. The resulting HGH is used by people who are unable to make their own. What property about hereditary information makes this possible?arrow_forwardPhenylketonuria (PKU) is a human hereditary disease resulting from the inability of the body to process the chemical phenylalanine, which is contained in the protein we eat. PKU is manifest in early infancy and, if it remains untreated, generally leads to cognitive impairment. PKU is caused by a recessive allele with simple Mendelian inheritance. A couple intends to have children but consults a genetic counselor because the man has a sister with PKU and the woman has a brother with PKU. There are no other known cases in their families. They ask the genetic counselor to determine the probability that their first child will have PKU. What is this probability?arrow_forward
- Hereditary hemochromatosis is an autosomal recessive genetic disorder that causes the body to absorb too much iron from the diet. This excess iron is stored in the body's tissues and organs, particularly the skin, heart, liver, pancreas, and joints. Because humans cannot increase the excretion of iron, excess iron can overload and eventually damage tissues and organs. A man who had hemophilia (an X-linked recessive genetic disorder), married a woman who had no family history of hemophilia whatsoever. The couple had consulted a genetic counselor when they first contemplated having children due to concerns that their future children might have hemophilia. Genetic testing of both future parents revealed that the husband did, in fact, possess the Hemophilia A allele but his wife was completely normal with respect to hemophilia. Much to their shock, their first child, a daughter, had a mild blood clotting disorder. Karyotyping was performed to determine whether this daughter had an…arrow_forwardThe following pedigree represents the inheritance of an autosomal recessive disease in a certain family. 2 5 2 4 5 8 3 4. 6. 1 1- How many males are affected by the disease? 3- How many children did the couple Il-4 and Il-5 have? 4- How many sisters did III-8 have? 5- What is the genotype of III-8? 40arrow_forwardPolydactyly is an autosomal dominant trait that results in the presence of additional digits on the hands and feet. The incidence in Caucasians is approximately 1 in every 1300 births while in Africans and African Americans, the prevalence is 1 in every ~150 births. Fortunately, this trait does not cause any deleterious effects on one's health. Actually, there are a number of individuals who have been successful football players that were born with polydactyly. In 1902, a study found that the allele frequency of the recessive allele (p) was 30% in the local population. Last year, a follow-up study was published which assessed the genotypes of the same local population. The following data were obtained: pp = 10%; Pp = 40%; PP = 50% Use the above information to answer the questions below. Use the word bank for a subquestion when provided. What is the frequency of p (recessive allele) in the follow-up study? Round your answer to the nearest tenth. Did the population evolve?…arrow_forward
- Tarzan and Jane are both normal, but their first child is affected with heroism, an autosomal recessive trait. What is the probability that their next child will also have the trait?arrow_forwardFanconi anemia is an autosomal recessive disease caused by a mutation in a single gene. It's a disease of the bone marrow. It results in decreased production of all types of blood cells. How can we tell from the pedigree that it is autosomal recessive?arrow_forwardXeroderma pigmentosum (XP) is a human disease which is autosomal recessive. It is a genetic mutation which negatively affects the body’s ability to repair thymine dimers. Without this ability to repair damage, the individual has a 1000-2000 times great chance of getting skin cancer. Suppose a woman who is a carrier for XP and marries a normal man. They have two children. One is normal and the other has XP. What is the genotype of the father?arrow_forward
- In man, muscular dystrophy is a condition in which the muscles waste away during early life and may result in a shorter life expectancy. It is due to a sex-linked, recessive gene. A certain couple has five children – three boys (ages 1yr, 3yrs, and 10yrs old) and two girls (ages 5yrs and 7yrs old). The oldest boy shows the symptoms of this disease. You are their family physician and they come to you for advice. What would you tell them about the chances of their other children developing the disease?arrow_forwardSickle Cell Anemia is caused by an abnormal form of haemoglobin, the part of the red blood cell that carries oxygen around the body. The red blood cells become stiff and block blood vessels, causing pain and damage and quickly destroying blood cells, leading to anemia. It is estimated that approximately 1 in 32 000 people in Canada are affected with sickle cell anemia.The disorder occurs when a person inherits two recessive genes for the condition. What are the frequencies of the recessive disease allele and the dominant normal allele in the population's gene pool? Select one: a. Recessive Allele Dominant Allele 0.559% 99.4% b. Recessive Allele Dominant Allele 5.59% 94.4% c. Recessive Allele Dominant Allele 0.313% 99.7% d. Recessive Allele Dominant Allele 0.00313% 99.9%arrow_forwardOne form of the bleeding disorder known as von Willebrand disease is an autosomal recessive disease. A man who is a carrier marries a woman who is also a carrier of the disease. (a) What percentage of their children are likely to have a disease phenotype? (b) What percentage of their children are likely to have a normal phenotype? (c) What percentage of their children are likely to be carriers of the disease?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSON
Biology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
Anatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY