The reason why X-linked recessive allele of muscular dystrophy may be present in the family of the employee which affected his son. Introduction: X-linked recessive alleles are expressed in homozygous individuals. Mother can be a carrier of the mutated X-linked recessive allele because she is heterozygous for the condition and did not develop any diseased condition.

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Biopharmaceutics and Pharmacokinetics:Two-Compartment Model Instant Absorption Questions Calculate these : a) B1, b) B2, c) hybrid rate constant (1) d) hybrid rate constant (2) e) t1/2,dist f) t1/2,elim g) k10 h) k12 i) k21 j) initial concentration (C0) k) central compartment volume (V1) l) steady-state volume (Vss) m) clearance (CL) AUC (0→10 min) using trapezoidal rule n) AUC (20→30 min) using trapezoidal rule o) AUCtail (AUC360→∞) p) total AUC (using short cut method) q) volume from AUC (VAUC)

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Chapter 11, Problem 7QP

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To explain: The reason why X-linked recessive allele of muscular dystrophy may be present in the family of the employee which affected his son.

Introduction: X-linked recessive alleles are expressed in homozygous individuals. Mother can be a carrier of the mutated X-linked recessive allele because she is heterozygous for the condition and did not develop any diseased condition.

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