The reason why X-linked recessive allele of muscular dystrophy may be present in the family of the employee which affected his son. Introduction: X-linked recessive alleles are expressed in homozygous individuals. Mother can be a carrier of the mutated X-linked recessive allele because she is heterozygous for the condition and did not develop any diseased condition.

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A genetics counselor, Nashaly Montez, notices an odd pattern in Devin’s pedigree, a propensity for cancer development in his family at a higher incidence in males compared to females. This suggests to Nashaly an X-linked recessive disorder that is not manifesting in females as frequently compared to males who only have one X chromosome. She brings this to the attention of Devin’s primary health care provider who has his client checked for common cancer-causing mutations. A mutant LOF Fox3 regulatory allele is found that has an early NONSENSE codon that prevents protein expression. This is unfortunate, since in its wildtype form the protein is normally tumor-suppressing. 1) If Devin’s mother is a carrier of the mutant LOF Fox3 gene, what is the likelihood he will inherit the defective X responsible for the condition. a 100% since he only inherits one X from his mother. b 25% due to the typical 3:1 ratio that manifests in recessive disorders. c 0% since he is…

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Chapter 11, Problem 7QP

Summary Introduction

To explain: The reason why X-linked recessive allele of muscular dystrophy may be present in the family of the employee which affected his son.

Introduction: X-linked recessive alleles are expressed in homozygous individuals. Mother can be a carrier of the mutated X-linked recessive allele because she is heterozygous for the condition and did not develop any diseased condition.

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A genetics counselor, Nashaly Montez, notices an odd pattern in Devin’s pedigree, a propensity for cancer development in his family at a higher incidence in males compared to females. This suggests to Nashaly an X-linked recessive disorder that is not manifesting in females as frequently compared to males who only have one X chromosome. She brings this to the attention of Devin’s primary health care provider who has his client checked for common cancer-causing mutations. A mutant LOF Fox3 regulatory allele is found that has an early NONSENSE codon that prevents protein expression. This is unfortunate, since in its wildtype form the protein is normally tumor-suppressing. 1) If Devin’s mother is a carrier of the mutant LOF Fox3 gene, what is the likelihood he will inherit the defective X responsible for the condition. a 100% since he only inherits one X from his mother. b 25% due to the typical 3:1 ratio that manifests in recessive disorders. c 0% since he is…

A genetics counselor, Nashaly Montez, notices an odd pattern in Devin’s pedigree, a propensity for cancer development in his family at a higher incidence in males compared to females. This suggests to Nashaly an X-linked recessive disorder that is not manifesting in females as frequently compared to males who only have one X chromosome. She brings this to the attention of Devin’s primary health care provider who has his client checked for common cancer-causing mutations. A mutant LOF Fox3 regulatory allele is found that has an early NONSENSE codon that prevents protein expression. This is unfortunate, since in its wildtype form the protein is normally tumor-suppressing. 1) Nashaly, the genetics counselor, is doing academic research on Fox 3 gene expression in a genetically engineered bacterial strain transfected with recombinant DNA. By exposing the bacterium to increased heat, she induces a mutation in the ribosome and not the gene. Transcripts can bind to the mutant ribosome…

In man, muscular dystrophy is a condition in which the muscles waste away during early life and may result in a shorter life expectancy. It is due to a sex-linked, recessive gene. A certain couple has five children – three boys (ages 1yr, 3yrs, and 10yrs old) and two girls (ages 5yrs and 7yrs old). The oldest boy shows the symptoms of this disease. You are their family physician and they come to you for advice. What would you tell them about the chances of their other children developing the disease?