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Examine the following peptide and the inserted table, and answer the 2 questions below: Thr-Glu-Pro-Ile-Val-Ala-Pro-Met-Glu-Tyr-Gly-Lys   1. Estimate the net charge of the peptide at pH 2.0. Explain. 2. Estimate the net charge of the peptide at pH 7.0. Explain.

Examine the following peptide and the inserted table, and answer the 2 questions below: Thr-Glu-Pro-Ile-Val-Ala-Pro-Met-Glu-Tyr-Gly-Lys   1. Estimate the net charge of the peptide at pH 2.0. Explain. 2. Estimate the net charge of the peptide at pH 7.0. Explain.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Examine the following peptide and the inserted table, and answer the 2 questions below:

Thr-Glu-Pro-Ile-Val-Ala-Pro-Met-Glu-Tyr-Gly-Lys

 

1. Estimate the net charge of the peptide at pH 2.0. Explain.

2. Estimate the net charge of the peptide at pH 7.0. Explain. 

**Table of Amino Acid Side Chain pKa Values** This table provides information on the typical pKa values of various amino acid groups. It lists the group name, its acid and base forms, and the corresponding typical pKa value. 1. **Terminal α-carboxyl group** - **Acid Form**: \(\text{COOH}\) - **Base Form**: \(\text{COO}^-\) - **Typical pKa**: 3.1 2. **Aspartic acid / Glutamic acid** - **Acid Form**: \(\text{COOH}\) - **Base Form**: \(\text{COO}^-\) - **Typical pKa**: 4.1 3. **Histidine** - **Acid Form**: \(\text{Imidazole ring with a positive charge (N)}^+\) - **Base Form**: \(\text{Imidazole ring (N)}\) - **Typical pKa**: 6.0 4. **Terminal α-amino group** - **Acid Form**: \(\text{NH}_3^+\) - **Base Form**: \(\text{NH}_2\) - **Typical pKa**: 8.0 5. **Cysteine** - **Acid Form**: \(\text{SH}\) - **Base Form**: \(\text{S}^-\) - **Typical pKa**: 8.3 6. **Lysine** - **Acid Form**: \(\text{NH}_3^+\) - **Base Form**: \(\text{NH}_2\) - **Typical pKa**: 10.8 7. **Tyrosine** - **Acid Form**: \(\text{Phenol}\) - **Base Form**: \(\text{Phenolate ion}\) - **Typical pKa**: 10.9 8. **Arginine** - **Acid Form**: \(\text{Guanidinium ion}\) - **Base Form**: \(\text{Guanidine}\) - **Typical pKa**: 12.5 Each entry includes a structural
Transcribed Image Text:**Table of Amino Acid Side Chain pKa Values** This table provides information on the typical pKa values of various amino acid groups. It lists the group name, its acid and base forms, and the corresponding typical pKa value. 1. **Terminal α-carboxyl group** - **Acid Form**: \(\text{COOH}\) - **Base Form**: \(\text{COO}^-\) - **Typical pKa**: 3.1 2. **Aspartic acid / Glutamic acid** - **Acid Form**: \(\text{COOH}\) - **Base Form**: \(\text{COO}^-\) - **Typical pKa**: 4.1 3. **Histidine** - **Acid Form**: \(\text{Imidazole ring with a positive charge (N)}^+\) - **Base Form**: \(\text{Imidazole ring (N)}\) - **Typical pKa**: 6.0 4. **Terminal α-amino group** - **Acid Form**: \(\text{NH}_3^+\) - **Base Form**: \(\text{NH}_2\) - **Typical pKa**: 8.0 5. **Cysteine** - **Acid Form**: \(\text{SH}\) - **Base Form**: \(\text{S}^-\) - **Typical pKa**: 8.3 6. **Lysine** - **Acid Form**: \(\text{NH}_3^+\) - **Base Form**: \(\text{NH}_2\) - **Typical pKa**: 10.8 7. **Tyrosine** - **Acid Form**: \(\text{Phenol}\) - **Base Form**: \(\text{Phenolate ion}\) - **Typical pKa**: 10.9 8. **Arginine** - **Acid Form**: \(\text{Guanidinium ion}\) - **Base Form**: \(\text{Guanidine}\) - **Typical pKa**: 12.5 Each entry includes a structural
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