Anatomy & Physiology
1st Edition
ISBN: 9781938168130
Author: Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher: OpenStax College
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Chapter 2, Problem 41CTQ
The pH of lemon juice is 2, and the pH of orange juice is 4. Which of these is more acidic, and by how much? What does this mean?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 2 Solutions
Anatomy & Physiology
Ch. 2 - Visit this website...Ch. 2 - Visit this website...Ch. 2 - Watch this video...Ch. 2 - Together, just four elements make up more than 95...Ch. 2 - The smallest unit of an element that still retains...Ch. 2 - The characteristic that gives an element its...Ch. 2 - On the periodic table of the elements, mercury...Ch. 2 - Nitrogen has an atomic number of seven. How many...Ch. 2 - Which of the following is a molecule, but not a...Ch. 2 - A molecule of ammonia contains one atom of...
Ch. 2 - When an atom donates an electron to another atom,...Ch. 2 - A substance formed of crystals of equal numbers of...Ch. 2 - Which of the following statements about chemical...Ch. 2 - The energy stored in a foot of snow on a steep...Ch. 2 - The bonding of calcium, phosphorus, and other...Ch. 2 - ABA+B is a general notation for a(n) ________...Ch. 2 - __________ reactions release energy. Catabolic...Ch. 2 - Which of the following combinations of atoms is...Ch. 2 - Chewing a bite of bread mixes it with saliva and...Ch. 2 - CH4 is methane. This compound is ________....Ch. 2 - Which of the following is most likely to be found...Ch. 2 - Jenny mixes up a batch of pancake batter, then...Ch. 2 - A substance dissociates into K+ and Cl- in...Ch. 2 - Ty is three years old and as a result of a stomach...Ch. 2 - C6H12O6 is the chemical formula for a ________....Ch. 2 - What organic compound do brain cells primarily...Ch. 2 - Which of the following is a functional group that...Ch. 2 - A pentose sugar is a part of the monomer used to...Ch. 2 - A phospholipid ________. has both polar and...Ch. 2 - In DNA, nucleotide bonding forms a compound with a...Ch. 2 - Uracil ________. contains nitrogen is a pyrimidine...Ch. 2 - The ability of an enzymes active sites to bind...Ch. 2 - The most abundant elements In the foods and...Ch. 2 - Oxygen, whose atomic number is eight, has three...Ch. 2 - Magnesium is an important element in the human...Ch. 2 - Explain why CH4 is one of the most common...Ch. 2 - In a hurry one day, you merely rinse your lunch...Ch. 2 - Could two atoms of oxygen engage in ionic bonding?...Ch. 2 - AB+CDAD+BE Is this a legitimate example of an...Ch. 2 - When you do a load of laundry, why do you not just...Ch. 2 - The pH of lemon juice is 2, and the pH of orange...Ch. 2 - During a party, Eli loses a bet and is forced to...Ch. 2 - If the disaccharide maltose is formed from two...Ch. 2 - Once dietary fats are digested and absorbed, why...
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