What is the charge of this peptide at pH 1.5?

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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What is the charge of this peptide at pH 1.5?

The image illustrates the chemical structure of a pentapeptide, which is a short chain composed of five amino acids linked by peptide bonds. These are represented by the following sequence from left to right:

1. **Glutamic Acid**: Its side chain is represented by -CH₂-CH₂-COOH.
2. **Valine**: Characterized by a branched side chain, -CH(CH₃)₂.
3. **Serine**: Contains a hydroxymethyl side chain, -CH₂-OH.
4. **Lysine**: Features a side chain of -(CH₂)₄-NH₂, indicating a primary amine group.
5. **Cysteine**: Noted for the presence of a thiol group in its side chain, -CH₂-SH.

The peptide bonds connecting these amino acids are highlighted by red ellipses. The structure emphasizes the linear arrangement of these amino acids through repeated N-C-C backbone units, a key characteristic of polypeptides. The terminal ends are shown as free amine (NH₂) and carboxyl (COOH) groups, typical of peptide chains.
Transcribed Image Text:The image illustrates the chemical structure of a pentapeptide, which is a short chain composed of five amino acids linked by peptide bonds. These are represented by the following sequence from left to right: 1. **Glutamic Acid**: Its side chain is represented by -CH₂-CH₂-COOH. 2. **Valine**: Characterized by a branched side chain, -CH(CH₃)₂. 3. **Serine**: Contains a hydroxymethyl side chain, -CH₂-OH. 4. **Lysine**: Features a side chain of -(CH₂)₄-NH₂, indicating a primary amine group. 5. **Cysteine**: Noted for the presence of a thiol group in its side chain, -CH₂-SH. The peptide bonds connecting these amino acids are highlighted by red ellipses. The structure emphasizes the linear arrangement of these amino acids through repeated N-C-C backbone units, a key characteristic of polypeptides. The terminal ends are shown as free amine (NH₂) and carboxyl (COOH) groups, typical of peptide chains.
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