There is parts A-D for the picture provided. A) A peptide has the sequence, Arg-Cys-His-Tyr-Glu-Asn-Lys-Asp. What is the net charge at pH 1? Choices: -5 -4 -3 -2 -1 0 +1 +2 +3 +4 +5
There is parts A-D for the picture provided. A) A peptide has the sequence, Arg-Cys-His-Tyr-Glu-Asn-Lys-Asp. What is the net charge at pH 1? Choices: -5 -4 -3 -2 -1 0 +1 +2 +3 +4 +5
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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There is parts A-D for the picture provided.
A) A peptide has the sequence, Arg-Cys-His-Tyr-Glu-Asn-Lys-Asp. What is the net charge at pH 1?
Choices:
-5
-4
-3
-2
-1
0
+1
+2
+3
+4
+5
B) A peptide has the sequence Arg-Cys-His-Tyr-Glu-Asn-Lys-Asp. What is the net charge at pH 5?
Choices:
-5
-4
-3
-2
-1
0
+1
+2
+3
+4
+5
C) Same Peptide sequence, What is the net charge at pH8.5, (N-terminus is pronated)
Choices:
-5
-4
-3
-2
-1
0
+1
+2
+3
+4
+5
D) A peptide has the sequence, Arg-Cys-His-Tyr-Glu-Asn-Lys-Asp. What is the net charge at pH 13?
Choices:
-5
-4
-3
-2
-1
0
+1
+2
+3
+4
+5
Thank You!
![Use the following information to answer the acid-base questions below.
pKa of main chain carboxylic acid = ~2
pKa of main chain amine group = ~10
Table of side-chain pkas:
AA pKa
Asp
Glu
Cys
Tyr
Lys
Arg
His
For acidic groups:
HA (aq)
pH
3.86
4.25
8.33
10.07
10.53
12.48
6.0
=
pH
+
An) + H
pKa + log
For basic groups:
+
HA(aq) →
(aq)
= pKa + log
[A-]
[HA]
A(aq) + H(aq)
[A]
[HA+]](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F3fb4eccc-7198-4ff0-ba32-4ca9cbdd36ee%2Fe107b28f-87d6-4351-8fe5-69e0b6f3d438%2Fsazygga_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Use the following information to answer the acid-base questions below.
pKa of main chain carboxylic acid = ~2
pKa of main chain amine group = ~10
Table of side-chain pkas:
AA pKa
Asp
Glu
Cys
Tyr
Lys
Arg
His
For acidic groups:
HA (aq)
pH
3.86
4.25
8.33
10.07
10.53
12.48
6.0
=
pH
+
An) + H
pKa + log
For basic groups:
+
HA(aq) →
(aq)
= pKa + log
[A-]
[HA]
A(aq) + H(aq)
[A]
[HA+]
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