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There is parts A-D for the picture provided. A) A peptide has the sequence, Arg-Cys-His-Tyr-Glu-Asn-Lys-Asp. What is the net charge at pH 1? Choices: -5 -4 -3 -2 -1 0 +1 +2 +3 +4 +5

There is parts A-D for the picture provided. A) A peptide has the sequence, Arg-Cys-His-Tyr-Glu-Asn-Lys-Asp. What is the net charge at pH 1? Choices: -5 -4 -3 -2 -1 0 +1 +2 +3 +4 +5

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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There is parts A-D for the picture provided.

A) A peptide has the sequence, Arg-Cys-His-Tyr-Glu-Asn-Lys-Asp. What is the net charge at pH 1?

Choices:

-5
-4
-3
-2
-1
0
+1
+2
+3
+4
+5
 
B) A peptide has the sequence Arg-Cys-His-Tyr-Glu-Asn-Lys-Asp. What is the net charge at pH 5?
 
Choices:
-5
-4
-3
-2
-1
0
+1
+2
+3
+4
+5
 
C) Same Peptide sequence, What is the net charge at pH8.5, (N-terminus is pronated)
Choices: 
 
-5
-4
-3
-2
-1
0
+1
+2
+3
+4
+5
 
D) A  peptide has the sequence, Arg-Cys-His-Tyr-Glu-Asn-Lys-Asp. What is the net charge at pH 13?
 
Choices:
-5
-4
-3
-2
-1
0
+1
+2
+3
+4
+5
 
Thank You!
Use the following information to answer the acid-base questions below. pKa of main chain carboxylic acid = ~2 pKa of main chain amine group = ~10 Table of side-chain pkas: AA pKa Asp Glu Cys Tyr Lys Arg His For acidic groups: HA (aq) pH 3.86 4.25 8.33 10.07 10.53 12.48 6.0 = pH + An) + H pKa + log For basic groups: + HA(aq) → (aq) = pKa + log [A-] [HA] A(aq) + H(aq) [A] [HA+]
Transcribed Image Text:Use the following information to answer the acid-base questions below. pKa of main chain carboxylic acid = ~2 pKa of main chain amine group = ~10 Table of side-chain pkas: AA pKa Asp Glu Cys Tyr Lys Arg His For acidic groups: HA (aq) pH 3.86 4.25 8.33 10.07 10.53 12.48 6.0 = pH + An) + H pKa + log For basic groups: + HA(aq) → (aq) = pKa + log [A-] [HA] A(aq) + H(aq) [A] [HA+]
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