When answering the questions below, please use the one-letter code for the amino acid, with NO spaces and symbols between each letter.1. What is the N-terminal AA residue?2. What is the C-terminal AA residue?3. What is the sequence of Peptide 1?4. What is the sequence of Peptide 4?5. What is the overall amino acid sequence? A NONAPEPTIDE that attacks and kills cancer cells has just been recently isolated from a rare fungus. Aminoacid analysis of the peptide reveals the following information below: (NOTE: when the sequence is not known,a comma separates the amino acids)HydrazineAcid Hydrolysis (6 N HCI) at 110°CNonapeptide(2) Arg, Gln, (2) Tyr, Gly, Ser, Thr, and Met2,4-dinitrofluorobenzeneDNP-ThrGin andmodified freeamino acidsPeptide 1(Arg, Thr, Ser)Cleavage with Trypsin, then chromatographyPeptide 2(Gly, Tyr, Arg)MetTripeptideCyanogen bromideDipeptidePeptide 3(Arg, Ser, Tyr, Thr)Cleavage with Chymotrypsin, then chromatographyAmino acidPeptide 4(Gly, Arg, Tyr)

Acid hydrolysis: Acid hydrolysis of any protein/polypeptide is being used to detect amino acids…

Answered: When answering the questions below,…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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A student was asked to draw the structure of the amino acids serine (R group is -CH₂OH) and glycine (R group is -H) linked by a peptide bond. The student was asked to place glycine at the N terminus and serine at the C terminus, label the peptide bond, and label the N- and C-termini. The student's drawing is shown below. Which of the following errors need to be corrected in the student's drawing? Check all that apply. Don't get overwhelmed by the number of options; just consider them one at a time. H H H peptide bond || N terminus H-N-C-C-N-C-C I | H H H-C-H I O-H C terminus OH The nitrogen flanking the peptide bond should be connected to hydrogen via a single bond as opposed to oxygen via a double bond The positions of the N and C flanking the peptide bond should be swapped the labels on the N and C termini need to be swapped a positive charge should be added to the N terminus The alpha carbon of glycine is missing a proton The peptide bond should be shifted one bond to the right The…
A sample of a peptide of unknown sequence was treated with trypsin; another sample of the same peptide was treated with chymotrypsin. The sequences (N-terminal to C-terminal) of the smaller peptides produced by trypsin digestion were as follows: Trp-Arg-Thr-Gin Ser-Trp-Arg-His-Trp-Ala-Lys Asp-Val-Ala-Ala-Lys Asn-Ser-Asn-Val-Ile-Arg The sequences of the smaller peptides produced by chymotrypsin digestion were as follows: Arg-His-Trp Arg-Thr-Gin Ala-Lys-Asn-Ser-Asn-Val-Ile-Arg-Trp Asp-Val-Ala-Ala-Lys-Ser-Trp The original peptide sequence was: Asp-Val-Ala-Ala-Lys-Ser-Trp-Ala-Lys-Asn-Ser-Asn-Val-Ile-Arg-Trp-Arg-His-Trp-Arg-Thr-Gin Asp-Val-Ala-Ala-Lys-Asn-Ser-Asn-Val-Ile-Arg-Trp-Arg-Thr-Gin-Ser-Trp-Arg-His-Trp-Ala-Lys Trp-Arg-Thr-Gin-Asn-Ser-Asn-Val-Ile-Arg-Ser-Trp-Arg-His-Trp-Ala-Lys-Asp-Val-Ala-Ala-Lys Arg-His-Trp-Arg-Thr-Gln-Ala-Lys-Asn-Ser-Asn-Val-Ile-Arg-Trp-Asp-Val-Ala-Ala-Lys-Ser-Trp Asp-Val-Ala-Ala-Lys-Ser-Trp-Arg-His-Trp-Ala-Lys-Asn-Ser-Asn-Val-Ile-Arg-Trp-Arg-Thr-Gin…
Form DIANINE name using the one-letter symbol and draw it as a peptide chain. Name the peptide as well.
What are the charges of the following amino acids peptides at ph 14? 1. GLAVV 2. RRKKQ
Enumerate all the possible DNA nucleotide base sequence for the amino acids given.
The following questions refer to this peptide: HOHHO || TT 11 HH OHH II H₂N-C-C-N-C-C-N-C-C-N-C-C H CH₂ 1 CH₂ SH CH₂ C=0 NH₂ 0 a) Write out the primary sequence of the peptide b) How many peptide bonds are present in this peptide c) How many disulfide bonds are present in this peptide
How do the "R" groups of amino acids contribute to the 3-D shape?
The following diagram of protein synthesis will be used for the next four questions. We will call this stretch of nucleic acid, Gene #1. Notice the letters located at various locations in the diagram. Those letters will be referenced in the following questions. D What is the structure labeled E in the protein synthesis diagram and what does it specify? Answer. What is the name of the process that occurs at letter X in the diagram? What would be the sequence of amino acids (and only amino acids) that would be produced from gene #1? Answer What effect would the deletion of structure C have on the process that accuns during step Y? Answer
a. How many peptide bonds are there? b. How many amino acid residues are there? c. In exact order, identify the name of the amino acids in the peptide chain. d. Give the full name of this peptide. e. Give the 3-letter abbreviation and 1-letter abbreviation. f. Calculate the pI of this peptide.
Can you explain the various options and how did you come to the answer? How to identify them when they are like that?
You are in the process of determining theamino acid sequence of a peptide. After trypsin digestion followedby the Edman degradation, you see the following peptide fragments:
A particular amino acid contains a -CH2NH3+ group. Is this amino acid more likely to be found on the inside or outside of the folded protein? Briefly explain.

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