A) Draw the "standard" base pairs (A:T and G:C) but instead of using the most common form of each base, use the uncommon tautomer form of each base (i.e. imino A, imino C, enol G, enol T). Clearly indicate hydrogen bonds (an arrow from donor to acceptor will suffice). Be sure to include the “R” representing the pentose. B) The G:U "wobble" base pair can be formed between the most common tautomer forms of G & U. Another base pair with the same geometry/pairing/orientation can be formed between G & T. Can you create a "wobble" base pair between the uncommon enol tautomer forms of G & T? Like the "wobble" G:U base pair in the Lecture 1 slides, this enol-based "wobble" G:T base pair must have at least two hydrogen bonds. If possible, draw such a base pair, and note any important differences from the non-enol G:U/T wobble. If it is not possible to draw such a base pair, explain why.
Nucleotides
It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).
Nucleic Acids
Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The structure of all proteins and ultimately every biomolecule and cellular component is a product of information encoded in the sequence of nucleic acids. Parts of a DNA molecule containing the information needed to synthesize a protein or an RNA are genes. Nucleic acids can store and transmit genetic information from one generation to the next, fundamental to any life form.
A) Draw the "standard" base pairs (A:T and G:C) but instead of using the most common form of each base, use the uncommon tautomer form of each base (i.e. imino A, imino C, enol G, enol T). Clearly indicate hydrogen bonds (an arrow from donor to acceptor will suffice). Be sure to include the “R” representing the pentose.
B) The G:U "wobble" base pair can be formed between the most common tautomer forms of G & U. Another base pair with the same geometry/pairing/orientation can be formed between G & T. Can you create a "wobble" base pair between the uncommon enol tautomer forms of G & T? Like the "wobble" G:U base pair in the Lecture 1 slides, this enol-based "wobble" G:T base pair must have at least two hydrogen bonds. If possible, draw such a base pair, and note any important differences from the non-enol G:U/T wobble. If it is not possible to draw such a base pair, explain why.
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