Please calculate and plot the charge on a peptide with the sequence of NEYK over the pH range from 1 to 13. Please use the pKa values from the table. You may calculate the charge at 1 pH unit intervals.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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Please calculate and plot the charge on a peptide with the sequence of NEYK over the pH range from 1 to 13. Please use the pKa values from the table. You may calculate the charge at 1 pH unit intervals.

The data presented is a comprehensive table of amino acids, featuring their properties and classifications. The table is organized into several columns and various groupings based on the nature of the R groups. Here, a detailed transcription is provided for an educational setting:

### Columns:

1. **Amino Acid**: The name of the amino acid.
2. **Abbreviation/Symbol**: The shorthand abbreviation and single-letter symbol for each amino acid.
3. **\( M_r \) (a)**: The relative molecular mass.
4. **\( pK_a \) values**: The dissociation constants for:
   - \( pK_1 \) (\(-COOH\))
   - \( pK_2 \) (\(-NH_3^+\))
   - \( pK_R \) (R group)
5. **pI**: The isoelectric point where the amino acid has no net charge.
6. **Hydropathy Index (b)**: A measure of hydrophobicity.
7. **Other Column (c)**: Not specified in the image, but appears as numerical values or footnotes related to specific properties.

### Groupings:

1. **Nonpolar, aliphatic R groups**:
   - Lists amino acids like Glycine, Alanine, Proline, Valine, Leucine, Isoleucine, and Methionine.

2. **Aromatic R groups**:
   - Includes Phenylalanine, Tyrosine, and Tryptophan.

3. **Polar, uncharged R groups**:
   - Consists of Serine, Threonine, Cysteine, Asparagine, and Glutamine.

4. **Positively charged R groups**:
   - Contains Lysine, Histidine, and Arginine.

5. **Negatively charged R groups**:
   - Comprises Aspartate and Glutamate.

### Key Data Highlights:

- **Glycine (Gly, G)**: Has a molecular mass of 75, a \( pK_1 \) value of 2.34, and a hydropathy index of -0.4.
- **Valine (Val, V)**: Has a higher hydropathy index (4.2) indicating more hydrophobic properties.
- **Glutamate (Glu, E)**: Has a negatively charged R group with a \( pI \) of
Transcribed Image Text:The data presented is a comprehensive table of amino acids, featuring their properties and classifications. The table is organized into several columns and various groupings based on the nature of the R groups. Here, a detailed transcription is provided for an educational setting: ### Columns: 1. **Amino Acid**: The name of the amino acid. 2. **Abbreviation/Symbol**: The shorthand abbreviation and single-letter symbol for each amino acid. 3. **\( M_r \) (a)**: The relative molecular mass. 4. **\( pK_a \) values**: The dissociation constants for: - \( pK_1 \) (\(-COOH\)) - \( pK_2 \) (\(-NH_3^+\)) - \( pK_R \) (R group) 5. **pI**: The isoelectric point where the amino acid has no net charge. 6. **Hydropathy Index (b)**: A measure of hydrophobicity. 7. **Other Column (c)**: Not specified in the image, but appears as numerical values or footnotes related to specific properties. ### Groupings: 1. **Nonpolar, aliphatic R groups**: - Lists amino acids like Glycine, Alanine, Proline, Valine, Leucine, Isoleucine, and Methionine. 2. **Aromatic R groups**: - Includes Phenylalanine, Tyrosine, and Tryptophan. 3. **Polar, uncharged R groups**: - Consists of Serine, Threonine, Cysteine, Asparagine, and Glutamine. 4. **Positively charged R groups**: - Contains Lysine, Histidine, and Arginine. 5. **Negatively charged R groups**: - Comprises Aspartate and Glutamate. ### Key Data Highlights: - **Glycine (Gly, G)**: Has a molecular mass of 75, a \( pK_1 \) value of 2.34, and a hydropathy index of -0.4. - **Valine (Val, V)**: Has a higher hydropathy index (4.2) indicating more hydrophobic properties. - **Glutamate (Glu, E)**: Has a negatively charged R group with a \( pI \) of
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