TABLE 5.1 Properties of the common amino acids found in proteins pK, of a-COOH Group pk, of a-NH Group pK, of lonizing Side Chain Abbreviations: 1- Residue Mass Occurrence in Name and 3-letter codes (daltons) Proteins (mol %) Alanine A, Ala 2.3 9.7 71.08 8.7 Arginine R, Arg 2.2 9.0 12.5 156.20 5.0 Asparagine N, Asn 2.0 8.8 114.11 4.2 D, Asp C, Cys Q, Gin E, Glu G, Gly Н, His I, lle Aspartic acid 2.1 9.8 3.9 115.09 5.9 Cysteine 1.8 10.8 8.3 103.14 1.3 Glutamine 2.2 9.1 128.14 3.7 Glutamic acid 2.2 9.7 4.2 129.12 6.6 Glycine 2.3 9.6 57.06 7.9 Histidine 1.8 9.2 6.0 137.15 2.4 Isoleucine 2.4 9.7 113.17 5.5 Leucine L, Leu 2.4 9.6 113.17 8.9 K, Lys М, Met F, Phe Lysine 2.2 9.0 10.0 128.18 5.5 Methionine 2.3 9.2 131.21 2.0 Phenylalanine 1.8 9.1 147.18 4.0 Proline P, Pro 2.0 10.6 97.12 4.7 Serine S, Ser 2.2 9.2 87.08 5.8 Threonine T, Thr 2.6 10.4 101.11 5.6 Tryptophan W, Trp 2.4 9.4 186.21 1.5 Tyrosine Y, Tyr 2.2 9.1 10.1 163.18 3.5 Valine V, Val 2.3 9.6 99.14 7.2
Nucleotides
It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).
Nucleic Acids
Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The structure of all proteins and ultimately every biomolecule and cellular component is a product of information encoded in the sequence of nucleic acids. Parts of a DNA molecule containing the information needed to synthesize a protein or an RNA are genes. Nucleic acids can store and transmit genetic information from one generation to the next, fundamental to any life form.
The melanocyte-stimulating peptide hormone α-melanotropin has the following sequence:
Ser–Tyr–Ser–Met–Glu–His–Phe–Arg–Trp–Gly–Lys–Pro–Val
(a) Write the sequence using the one-letter abbreviations.
(b) Calculate the molecular weight of α-melanotropin, using data in as shown.
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