Hydrolysis of dodecapeptide P with the enzyme trypsin affords the following fragments: Arg,Ser-Tyr-Ser-Met-Lys, Ala-Gly-Asp-Phe-Glu-Arg.Hydrolysis with chymotrypsin yields: Glu-Arg, Arg-Ser-Tyr, Ser-Met-Lys-Ala-Gly-Asp-Phe.What is the amino acid sequence of P?Submit AnswerRetry Entire Group 9 more group attempts remaining

Trypsin and chymotrypsin are the proteolytic enzymes that can cleave peptide bonds of proteins with…

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Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Identify the primary sequence for the polypeptide that yields these fragments upon treatment: His-met-thr-met-ala-trp; Leu-asn-asp-phe; Val-lys obtained from chymotrypsin Leu-asn-asp-phe-his-met; Ala-trp-val-lys; Thr-met obtained from CNBR
Draw a schematic of the chemical structure of the Leu-Tyr-Met-Lys tetrapeptide, with the correct ionization at neutral pH (pH 7). Also, give an estimate the pl of this tetrapeptide (you are given that the pKa of any acidic R group is 4, the pKa of any basic R group is 11.5, and the pKa of the α-COOH is 2, and the a-NH3 is 9.5). Provide rationale!
a) This molecule is produced when what amino acid is transaminated? b) What are the one- and three-letter abbreviations for this amino acid?
In each of the following pairs of amino acids, identify which amino acid would be more soluble in water: (a) Ala, Leu; (b) Tyr, Phe; (c) Ser, Ala; (d) Trp, His
What is the net charge at pH 7 on a peptide with the following sequence? Gly-Ala-Lys-Phe-Asp-Met-Val-Pro-Arg-Ala-Leu
The primary structure of b-endorphin, a peptide containing 31 amino acids synthesized by the body to control pain, is shown here: Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr- Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu What fragments are obtained as a result of treatment withcyanogen bromide?
61. The correct name of the peptide below is, * H2N- -CH-C-N- -CH-C- -CH-C -N-CH-C- -OH H ČH3 CH-CH3 CH2 ČH3 a) Gly-Leu-lle-Thr b) Ser-Val-Ala-Gly c) Gly-Ala-Val-Ser d) Thr-lle-Lue-Gly
g) (CH3)₂ - CH₂ -CH-COOH + CH₂-CH-COOH -H₂O NH₂ OH NH₂ 4. Write the equation for the digestion (hydrolysis) of Phe-Asp-Ala. €
Based on the following image, what is the N-terminal AA residue, C-terminal AA residue? What is also the sequence of peptide 2 and peptide 3? Also identify the overall amino acid sequence
Given is a polypepetide in the presence of the enzyme pepsin. N-gly-arg-met-phe-ala-lys-ser-tyr-gly C, What fragments can be formed? choices are below gly-arg-met + phe-ala-lys-ser + tyr-gly gly-arg-met-phe + ala-lys-ser-tyr + gly gly + arg-met-phe-ala + lys-aer-tyr-gly gly-arg + met-phe-ala +lys +ser=tyr=gly
Draw the tetrapeptide Met-Ile-Lys-Glu at a ph of 7?
The melanocyte-stimulating hormone a-melanotropin has the following sequence: Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val In the one-letter code of amino acids, this sequence would be: SYSMEHFRWGKPV STSMGHFAWGKPV O SYSMDHFAWGKPV O SYSMEHFAWGLPV

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