Draw the sequence of events that lead to kinesin heads moving along a protofilament of a microtubule. Start with the leading head( label #1) bound to the protofilament but not associated with a nucleotide and the lagging head(label #2) loosely associated with the protofilament and bound to ADP Represent the events that occur that lead to head #2 advancing in front of head #1. Your drawing should accurately represent the conformational changes in the neck linker and type of nucleotide bound to kinesin. Label the tubulin dimers ( alpha, beta), neck linkers, coiled coil , and the polarity of the protofilament( plus end , minus end). Use arrows to indicate direction of movement.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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1.
Draw the sequence of events that lead to kinesin heads moving along a
protofilament of a microtubule. Start with the leading head( label #1) bound
to the protofilament but not associated with a nucleotide and the lagging
head(label #2) loosely associated with the protofilament and bound to ADP
Represent the events that occur that lead to head #2 advancing in front of
head #1. Your drawing should accurately represent the conformational
changes in the neck linker and type of nucleotide bound to kinesin. Label the
tubulin dimers ( alpha, beta), neck linkers, coiled coil , and the polarity of the
protofilament( plus end , minus end). Use arrows to indicate direction of
movement.
Transcribed Image Text:1. Draw the sequence of events that lead to kinesin heads moving along a protofilament of a microtubule. Start with the leading head( label #1) bound to the protofilament but not associated with a nucleotide and the lagging head(label #2) loosely associated with the protofilament and bound to ADP Represent the events that occur that lead to head #2 advancing in front of head #1. Your drawing should accurately represent the conformational changes in the neck linker and type of nucleotide bound to kinesin. Label the tubulin dimers ( alpha, beta), neck linkers, coiled coil , and the polarity of the protofilament( plus end , minus end). Use arrows to indicate direction of movement.
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