A small peptide has two pKa values of 3.42 and 8.74. What is the isoelectric point for this peptide? Report your answer as a number below to three significant figures
A small peptide has two pKa values of 3.42 and 8.74. What is the isoelectric point for this peptide? Report your answer as a number below to three significant figures
Chapter11: Health Of Aquatic Animals
Section: Chapter Questions
Problem 3KA
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A small peptide has two pKa values of 3.42 and 8.74. What is the isoelectric point for this peptide? Report your answer as a number below to three significant figures
Expert Solution
Step 1
Isoelectric point: The isoelectric point(pI) is the pH at which a particular molecule carries no net electrical charge. The net charge on the molecule is affected by the pH of its surrounding environment. It is the mean of Pka values for a molecule, Mathematically. The pKa of each amino component amino acid determines the pI of a protein.
pI = 1/2 (pKa1 + pKa2)
pI = 1/2 (3.42 + 8.74 )
pI = 1/2 (12.16)
pI = 7.79
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