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If you express a Rab with a mutation in its GEF binding domain in cells, you would observe the following phenotype. OA. No actin polymerization B. No nuclear import OC. No vesicular transport D. No signal transduction

If you express a Rab with a mutation in its GEF binding domain in cells, you would observe the following phenotype. OA. No actin polymerization B. No nuclear import OC. No vesicular transport D. No signal transduction

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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If you express a Rab with a mutation in its GEF binding domain in cells, you would observe the following phenotype. A. No actin polymerization B. No nuclear import C. No vesicular transport D. No signal transduction
Transcribed Image Text:If you express a Rab with a mutation in its GEF binding domain in cells, you would observe the following phenotype. A. No actin polymerization B. No nuclear import C. No vesicular transport D. No signal transduction
You are studying a cytoskeletal accessory protein, AB2. You believe it is involved in receptor-mediated endocytosis allowing for the entry of a novel virus, SARS-CoV X, into the host cell. To confirm that AB2 is required for viral entry, you engineer an AB2 protein containing an N-terminal hydrophobic signal sequence and a C-terminal KDEL sequence (AB2-SSKDEL) and express it in human epithelial airway cells. You compare cells expressing wild-type (WT) AB2 (lacking the signal sequence and KDEL sequence) with cells expressing AB2-SSKDEL. You are looking at the entry of a GFP (green) virus into cells. If AB2 is required for viral entry, via receptor-mediated endocytosis, what results would you expect to see in terms of viral entry? A. WT AB2 - Green ER AB2-SSKDEL - No green ER B. WT AB2-NO green cells AB2-SSKDEL - Many green cells OC. WT AB2 - Many green cells AB2-SSKDEL - NO green cells D.WT AB2 - Green nuclei AB2-SSKDEL - No green nuclei
Transcribed Image Text:You are studying a cytoskeletal accessory protein, AB2. You believe it is involved in receptor-mediated endocytosis allowing for the entry of a novel virus, SARS-CoV X, into the host cell. To confirm that AB2 is required for viral entry, you engineer an AB2 protein containing an N-terminal hydrophobic signal sequence and a C-terminal KDEL sequence (AB2-SSKDEL) and express it in human epithelial airway cells. You compare cells expressing wild-type (WT) AB2 (lacking the signal sequence and KDEL sequence) with cells expressing AB2-SSKDEL. You are looking at the entry of a GFP (green) virus into cells. If AB2 is required for viral entry, via receptor-mediated endocytosis, what results would you expect to see in terms of viral entry? A. WT AB2 - Green ER AB2-SSKDEL - No green ER B. WT AB2-NO green cells AB2-SSKDEL - Many green cells OC. WT AB2 - Many green cells AB2-SSKDEL - NO green cells D.WT AB2 - Green nuclei AB2-SSKDEL - No green nuclei
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