Receptor downregulation often occurs via endocytosis as a means of turning off a signaling pathway. How does receptor- mediated endocytosis result in turning off signaling? O A. Receptor-mediated endocytosis shuts off signaling through polyubiquitination and degradation of the receptor by the proteasome. O B, It doesn't. Signaling continues until the endosome fuses with the lysosome. OC, Signaling is shut off rapidly through the budding of endosomes into themselves forming multivesicular bodies. This sequesters the cytoplasmic tail from intracellular signaling proteins. O D. Receptor-mediated endocytosis shuts off signaling by sorting receptors to recycling endosomes.
Receptor downregulation often occurs via endocytosis as a means of turning off a signaling pathway. How does receptor- mediated endocytosis result in turning off signaling? O A. Receptor-mediated endocytosis shuts off signaling through polyubiquitination and degradation of the receptor by the proteasome. O B, It doesn't. Signaling continues until the endosome fuses with the lysosome. OC, Signaling is shut off rapidly through the budding of endosomes into themselves forming multivesicular bodies. This sequesters the cytoplasmic tail from intracellular signaling proteins. O D. Receptor-mediated endocytosis shuts off signaling by sorting receptors to recycling endosomes.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:**Understanding Receptor-Mediated Endocytosis in Signal Regulation**
**Question:**
Receptor downregulation often occurs via endocytosis as a means of turning off a signaling pathway. How does receptor-mediated endocytosis result in turning off signaling?
**Answer Choices:**
- **A.** Receptor-mediated endocytosis shuts off signaling through polyubiquitination and degradation of the receptor by the proteasome.
- **B.** It doesn't. Signaling continues until the endosome fuses with the lysosome.
- **C.** Signaling is shut off rapidly through the budding of endosomes into themselves forming multivesicular bodies. This sequesters the cytoplasmic tail form intracellular signaling proteins.
- **D.** Receptor-mediated endocytosis shuts off signaling by sorting receptors to recycling endosomes. *(Correct Answer)*
**Explanation:**
The correct option is D. Receptor-mediated endocytosis is a key mechanism in cellular signal regulation. By sequestering receptors and sorting them to recycling endosomes, the cell can effectively shut down signaling pathways. This process allows the cell to control and moderate internal responses to external stimuli efficiently.
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