Receptor downregulation often occurs via endocytosis as a means of turning off a signaling pathway. How does receptor- mediated endocytosis result in turning off signaling? O A. Receptor-mediated endocytosis shuts off signaling through polyubiquitination and degradation of the receptor by the proteasome. O B, It doesn't. Signaling continues until the endosome fuses with the lysosome. OC, Signaling is shut off rapidly through the budding of endosomes into themselves forming multivesicular bodies. This sequesters the cytoplasmic tail from intracellular signaling proteins. O D. Receptor-mediated endocytosis shuts off signaling by sorting receptors to recycling endosomes.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
icon
Related questions
Question
**Understanding Receptor-Mediated Endocytosis in Signal Regulation**

**Question:**
Receptor downregulation often occurs via endocytosis as a means of turning off a signaling pathway. How does receptor-mediated endocytosis result in turning off signaling?

**Answer Choices:**
- **A.** Receptor-mediated endocytosis shuts off signaling through polyubiquitination and degradation of the receptor by the proteasome.

- **B.** It doesn't. Signaling continues until the endosome fuses with the lysosome.

- **C.** Signaling is shut off rapidly through the budding of endosomes into themselves forming multivesicular bodies. This sequesters the cytoplasmic tail form intracellular signaling proteins.

- **D.** Receptor-mediated endocytosis shuts off signaling by sorting receptors to recycling endosomes. *(Correct Answer)*

**Explanation:** 
The correct option is D. Receptor-mediated endocytosis is a key mechanism in cellular signal regulation. By sequestering receptors and sorting them to recycling endosomes, the cell can effectively shut down signaling pathways. This process allows the cell to control and moderate internal responses to external stimuli efficiently.
Transcribed Image Text:**Understanding Receptor-Mediated Endocytosis in Signal Regulation** **Question:** Receptor downregulation often occurs via endocytosis as a means of turning off a signaling pathway. How does receptor-mediated endocytosis result in turning off signaling? **Answer Choices:** - **A.** Receptor-mediated endocytosis shuts off signaling through polyubiquitination and degradation of the receptor by the proteasome. - **B.** It doesn't. Signaling continues until the endosome fuses with the lysosome. - **C.** Signaling is shut off rapidly through the budding of endosomes into themselves forming multivesicular bodies. This sequesters the cytoplasmic tail form intracellular signaling proteins. - **D.** Receptor-mediated endocytosis shuts off signaling by sorting receptors to recycling endosomes. *(Correct Answer)* **Explanation:** The correct option is D. Receptor-mediated endocytosis is a key mechanism in cellular signal regulation. By sequestering receptors and sorting them to recycling endosomes, the cell can effectively shut down signaling pathways. This process allows the cell to control and moderate internal responses to external stimuli efficiently.
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education