You are working in a lab studying Progeria. You design an expression vector containing a mutated form of the lamin gene that codes for a lamin protein that can no longer be phosphorylated. What do you predict would happen if you express this mutant form of lamin in a cell line? Lamin proteins would not be transported into the nucleus and would remain in the cytosol. Nuclear lamins will be unable to produce dimers, as the coiled-coil formation will be disrupted. Disassembly of the nuclear lamins will occur prematurely. Nuclear lamins will no longer disassemble properly during prometaphase. O Nuclear lamins will no longer assemble properly during telophase. O O O O

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
icon
Related questions
Topic Video
Question
You are working in a lab studying Progeria. You design an expression vector containing a mutated
form of the lamin gene that codes for a lamin protein that can no longer be phosphorylated. What
do you predict would happen if you express this mutant form of lamin in a cell line?
Lamin proteins would not be transported into the nucleus and would remain in the cytosol.
Nuclear lamins will be unable to produce dimers, as the coiled-coil formation will be disrupted.
Disassembly of the nuclear lamins will occur prematurely.
Nuclear lamins will no longer disassemble properly during prometaphase.
O Nuclear lamins will no longer assemble properly during telophase.
Transcribed Image Text:You are working in a lab studying Progeria. You design an expression vector containing a mutated form of the lamin gene that codes for a lamin protein that can no longer be phosphorylated. What do you predict would happen if you express this mutant form of lamin in a cell line? Lamin proteins would not be transported into the nucleus and would remain in the cytosol. Nuclear lamins will be unable to produce dimers, as the coiled-coil formation will be disrupted. Disassembly of the nuclear lamins will occur prematurely. Nuclear lamins will no longer disassemble properly during prometaphase. O Nuclear lamins will no longer assemble properly during telophase.
Expert Solution
steps

Step by step

Solved in 3 steps

Blurred answer
Knowledge Booster
Gene expression
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education