The three irriversible reactions in glycosis is :  Hexoknase, PFK-1 and Pryvate kinases. they are all enzymes, why these three enzymes are irriversible? the explaination below is not very understandble.  "Hexokinase: This enzyme catalyzes the conversion of glucose to glucose-6-phosphate. This reaction consumes ATP and traps glucose inside the cell by converting it into a charged and phosphorylated form. Phosphofructokinase-1 (PFK-1): This enzyme catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate. This reaction is the committed step of glycolysis, and it is also the main regulatory point of the pathway. PFK-1 is allosterically inhibited by ATP and citrate and activated by AMP and fructose-2,6-bisphosphate. Pyruvate kinase: This enzyme catalyzes the conversion of phosphoenolpyruvate (PEP) to pyruvate, producing ATP. This reaction is the last step of glycolysis and is also highly regulated. Pyruvate kinase is allosterically activated by fructose-1,6-bisphosphate and inhibited by ATP and alanine."

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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The three irriversible reactions in glycosis is :  Hexoknase, PFK-1 and Pryvate kinases. they are all enzymes, why these three enzymes are irriversible? the explaination below is not very understandble. 

"Hexokinase: This enzyme catalyzes the conversion of glucose to glucose-6-phosphate. This reaction consumes ATP and traps glucose inside the cell by converting it into a charged and phosphorylated form.

Phosphofructokinase-1 (PFK-1): This enzyme catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate. This reaction is the committed step of glycolysis, and it is also the main regulatory point of the pathway. PFK-1 is allosterically inhibited by ATP and citrate and activated by AMP and fructose-2,6-bisphosphate.

Pyruvate kinase: This enzyme catalyzes the conversion of phosphoenolpyruvate (PEP) to pyruvate, producing ATP. This reaction is the last step of glycolysis and is also highly regulated. Pyruvate kinase is allosterically activated by fructose-1,6-bisphosphate and inhibited by ATP and alanine."

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Do you mean that "reaction themodynamically favorable" is the same as irreversible? 

PFK-1 conversion of Pyruvate is ADP to ATP, how would you explain this? 

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What does the high-energy molecules adenosine triphosphate fforms and reduced forms of nicotinamide adenine dinucleotide means? 

 

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