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How do ATP levels regulate glycolysis? 00 High levels of ATP enhance glycolysis ATP levels do not affect glycolysis. High levels of ATP inhibit glycolysis.

How do ATP levels regulate glycolysis? 00 High levels of ATP enhance glycolysis ATP levels do not affect glycolysis. High levels of ATP inhibit glycolysis.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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**Question:** How do ATP levels regulate glycolysis? - ○ High levels of ATP enhance glycolysis. - ○ ATP levels do not affect glycolysis. - ○ High levels of ATP inhibit glycolysis.
Transcribed Image Text:**Question:** How do ATP levels regulate glycolysis? - ○ High levels of ATP enhance glycolysis. - ○ ATP levels do not affect glycolysis. - ○ High levels of ATP inhibit glycolysis.
The graph illustrates the effect of ATP on the allosteric enzyme phosphofructokinase-1 (PFK-1). **Graph Description:** - The x-axis represents the concentration of ATP. - The y-axis shows PFK-1 activity as a percentage of V(max), which is the maximum rate of the enzyme-catalyzed reaction. Two curves are depicted: 1. **Low [ADP] Curve**: - This curve rises quickly with increasing [ATP], reaching a peak around 80% of V(max), and then drops sharply as [ATP] continues to increase. 2. **High [ADP] Curve**: - This curve also rises with increasing [ATP] but reaches a higher peak above 80% of V(max) than the low [ADP] curve. It also declines, but the decline starts at a higher ATP concentration compared to the low [ADP] curve. **Explanation:** For a given concentration of fructose 6-phosphate, the activity of PFK-1 increases with increasing concentrations of ATP. However, there is a threshold beyond which further increases in ATP concentration inhibit the enzyme's activity. The presence of ADP shifts the peak of enzyme activity, indicating its role in modulating PFK-1's sensitivity to ATP.
Transcribed Image Text:The graph illustrates the effect of ATP on the allosteric enzyme phosphofructokinase-1 (PFK-1). **Graph Description:** - The x-axis represents the concentration of ATP. - The y-axis shows PFK-1 activity as a percentage of V(max), which is the maximum rate of the enzyme-catalyzed reaction. Two curves are depicted: 1. **Low [ADP] Curve**: - This curve rises quickly with increasing [ATP], reaching a peak around 80% of V(max), and then drops sharply as [ATP] continues to increase. 2. **High [ADP] Curve**: - This curve also rises with increasing [ATP] but reaches a higher peak above 80% of V(max) than the low [ADP] curve. It also declines, but the decline starts at a higher ATP concentration compared to the low [ADP] curve. **Explanation:** For a given concentration of fructose 6-phosphate, the activity of PFK-1 increases with increasing concentrations of ATP. However, there is a threshold beyond which further increases in ATP concentration inhibit the enzyme's activity. The presence of ADP shifts the peak of enzyme activity, indicating its role in modulating PFK-1's sensitivity to ATP.
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