Glucose-6 Phosphate Dehydrogenase and TPI Deficiencies 2 H+ Glucose-6-P GSH + GSH Reduced glutathione NADP+ Glucose-6-phosphate dehydrogenase H₂O₂ Hydrogen peroxide 0₂- Superoxide radical NADPH + H+ 6-Phosphogluconolactone GSSG Glutathione Oxidized reductase Glutathione peroxidase Aerobic respiration, drugs, fava beans glutathione 2 H₂O Detoxification ……………………… 0₂ SOD: superoxide dismutase GPx: glutathione peroxidase HK: hexokinase GSSG and GSH: glutathione, oxidized and reduced forms, respectively. CAT: catalase The diagram above gives important details about the HMP shunt. Superoxides/free radicals dis- rupt membrane lipids, causing changes in membrane permeability. The HMP shunt is expressed in liver cells, red blood cells, and in lipid-producing tissues. 1. Discuss how glycolysis is affected in G6PD patients, using the diagrams to explain your response. 2. How does this effect differ from TPI patients? 3. Why are red blood cells, but not the nervous system, affected in G6PD patients?
Glucose-6 Phosphate Dehydrogenase and TPI Deficiencies 2 H+ Glucose-6-P GSH + GSH Reduced glutathione NADP+ Glucose-6-phosphate dehydrogenase H₂O₂ Hydrogen peroxide 0₂- Superoxide radical NADPH + H+ 6-Phosphogluconolactone GSSG Glutathione Oxidized reductase Glutathione peroxidase Aerobic respiration, drugs, fava beans glutathione 2 H₂O Detoxification ……………………… 0₂ SOD: superoxide dismutase GPx: glutathione peroxidase HK: hexokinase GSSG and GSH: glutathione, oxidized and reduced forms, respectively. CAT: catalase The diagram above gives important details about the HMP shunt. Superoxides/free radicals dis- rupt membrane lipids, causing changes in membrane permeability. The HMP shunt is expressed in liver cells, red blood cells, and in lipid-producing tissues. 1. Discuss how glycolysis is affected in G6PD patients, using the diagrams to explain your response. 2. How does this effect differ from TPI patients? 3. Why are red blood cells, but not the nervous system, affected in G6PD patients?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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