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which statements are False

which statements are False

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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which statements are False 

**a.** In the TCA Cycle, 3 molecules of NADH are produced per molecule of Acetyl-CoA oxidized. **b.** Intracellular concentrations in resting muscle are as follows: - Fructose-6-phosphate (1.0 mM) - Fructose-(1-6)-bisphosphate (10.0 mM) - AMP (0.1 mM) - ADP (0.5 mM) - ATP (5.0 mM) - Pi (10.0 mM) Under these conditions, the Phosphofructokinase reaction in muscle is more exergonic than under standard conditions. **c.** The E₂ component of the Pyruvate Dehydrogenase complex binds NAD⁺ in its active site. **d.** If ¹⁴CO₂ was bubbled through a suspension of liver cells undergoing gluconeogenesis from lactate to glucose, carbons 1 and 6 of glucose would be radioactive. **e.** When Acetyl-CoA levels exceed the Oxaloacetate supply, allosteric activation of Pyruvate Carboxylase by Acetyl-CoA raises Oxaloacetate levels for condensation with Acetyl-CoA to form Citrate. **f.** The carbon atom of the -COO group attached to the keto carbon of Oxaloacetate is released as carbon dioxide in the Isocitrate Dehydrogenase reaction. **g.** The two electrons derived from the Pyruvate Dehydrogenase complex come from dihydrolipoic acid. **h.** The reaction of Malate oxidation to Oxaloacetate occurs because Oxaloacetate is used in the next reaction, which has a negative ΔG. **i.** The only reaction in the Citric Acid Cycle that provides substrate-level phosphorylation is catalyzed by Succinyl CoA Synthetase.
Transcribed Image Text:**a.** In the TCA Cycle, 3 molecules of NADH are produced per molecule of Acetyl-CoA oxidized. **b.** Intracellular concentrations in resting muscle are as follows: - Fructose-6-phosphate (1.0 mM) - Fructose-(1-6)-bisphosphate (10.0 mM) - AMP (0.1 mM) - ADP (0.5 mM) - ATP (5.0 mM) - Pi (10.0 mM) Under these conditions, the Phosphofructokinase reaction in muscle is more exergonic than under standard conditions. **c.** The E₂ component of the Pyruvate Dehydrogenase complex binds NAD⁺ in its active site. **d.** If ¹⁴CO₂ was bubbled through a suspension of liver cells undergoing gluconeogenesis from lactate to glucose, carbons 1 and 6 of glucose would be radioactive. **e.** When Acetyl-CoA levels exceed the Oxaloacetate supply, allosteric activation of Pyruvate Carboxylase by Acetyl-CoA raises Oxaloacetate levels for condensation with Acetyl-CoA to form Citrate. **f.** The carbon atom of the -COO group attached to the keto carbon of Oxaloacetate is released as carbon dioxide in the Isocitrate Dehydrogenase reaction. **g.** The two electrons derived from the Pyruvate Dehydrogenase complex come from dihydrolipoic acid. **h.** The reaction of Malate oxidation to Oxaloacetate occurs because Oxaloacetate is used in the next reaction, which has a negative ΔG. **i.** The only reaction in the Citric Acid Cycle that provides substrate-level phosphorylation is catalyzed by Succinyl CoA Synthetase.
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