Cystic fibrosis is a genetic disease caused by mutations in the CFTR gene. The consequence of this is the production of an abnormal transmembrane protein that is responsible for producing sweat, mucus, and digestive fluids. Explain in depth the correlation between the defective gene and the abnormal protein that is produced. Be sure to mention the process involved in protein production, whether or not those process(s) have properly occurred, and their end products.

Q: Having identified a different level of a particular collagen type in the mutant C. elegans strains,…

A: A particular type of collagen is found to be expressed at a different level in the mutant strain of…

Q: The determination of the mass of a protein by mass spectrometry often does not allow its unique…

A: Trypsin : It is an enzyme that helps us digestion protein. In the small intestine, trypsin breaks…

Q: In eukaryotic cells, secreted proteins are initially directed to the endoplasmic reticulum and then…

A: Introduction The secretory pathway refers to the endoplasmic reticulum, Golgi apparatus and the…

Q: The eukaryotic metallothionein gene promoter consists of all EXCEPT:

A: A promoter is a region of DNA where RNA polymerase begins to transcribe a gene.

Q: Both ADA-SCID and type I diabetes are diseases based on lack of a particular protein. Why has the…

A: ADA means Adenosine deaminase deficiency and SCID is severe combined immunodeficiency.  ADA-SCID is…

Q: is the various steps of protein production in eukaryotic cells and their localization (from a gene…

A: Protein is a very important part of the cell because it it is the ultimate machinery through which…

Q: 5. Calculate molecular weight (kiloDalton, kD) and calculated pI (the pH where the protein carries…

A: 5) To calculate molecular weight (KiloDalton [kD]) and the calculated pI of the protein, submit the…

Q: Describe instances when a DNA mutation would not alter the function of a protein. Describe instances…

A: Genetic material is nothing but the sequence of nucleic acids which is called as DNA. It contains…

Q: Explain why protein glycosylation may determine the choice of a protein expression system

A: Proteins are polymers of amino acids. The steps in the formation of a protein are the transcription…

Q: Assume that during the process of creating the SHH protein an error was made. Instead of producing a…

A: The lumen of the endoplasmic reticulum has several chaperones that assist in the folding of…

Q: Cystic Fibrosis is a genetically heritable disease caused by the loss of the chloride channel, CFTR.…

A: Cystic fibrosis is a genetic disease that is characterized by the production of excessively thick…

Q: Determine the reason due to which it is possible that the translation of a single mitochondrial…

A: Given that tRNAs are impacted by numerous clinical mitochondrial illnesses brought on by mutations…

Q: Like Hurler syndrome, Fabry disease involves an abnormal accumulationof substances within lysosomes.…

A: Fabry disease can be defined as the type of rare genetic disorder in which there is an accumulation…

Q: Determine the effect of the following mutations on the DNA sequence. In each case, the mutation is…

A: The mutation is a process that causes changes in the DNA sequence and that effect the amino acid…

Q: A significant number of mutations in the HBB gene that cause human b@thalassemia occur within…

A: Introduction: HBB is also known as beta-globin, hemoglobin, etc. It is a globin protein encoded by…

Q: Discuss the following statement: “from the nucleotide sequence of a cDNA clone, the complete amino…

A: The proteins are the polymer of amino acids. They play an important role in the cell, by catalyzing…

Q: A transmembrane protein is positioned such that the N-terminus and C-terminus are directed towards…

A: Based on the property of amino acids they found in the intracellular and extracellular environment.

Q: In many genetic disorders, a lysosomal enzyme required to degrade a specific molecule is missing or…

A: Tay–Sachs disease is an inherited disorder that causes the destruction of neurons in the spinal cord…

Q: Identify the type of mutation present in the CDS and discuss the implications on the protein.

A: Mutations are random alteration in the DNA structure which leads to mis-reading of Information on…

Q: Silent mutations that occur in DNA are quite common in living cells and usually involve no effects…

A: A gene mutation is a permanent alteration that makes up a gene in the DNA sequence, so that the…

Q: As we focused on the translation of mRNA into proteins as well as on protein structure and function.…

A: One gene one enzyme hypothesis, proposed by Beadle and Tatum, says that each enzyme produces a…

Q: Cystic fibrosis (CF) is an inherited disorder caused by different types of mutations, many of which…

A: CF is caused by a mutation in a gene called the cystic fibrosis transmembrane conductance regulator…

Q: Name four types of point mutations that can occur in a gene coding for a protein. Discuss the…

A: The DNA (deoxyribonucleic acid) is the double-stranded molecule that is the genetic material in most…

Q: The tumor suppressor pRB also binds to and suppresses the activity of retinoblastoma-binding protein…

A: Mutation in genes is the process of change in the nucleotide sequence of the genome.

Q: Like Hurler syndrome, Fabry disease involves an abnormal accumulationof substances within lysosomes.…

A: Gene is a functional unit of heredity. A gene is a sequence of nucleotides in genome that codes for…

Q: Identify a disease or condition related to protein mis-folding.  Which protein is misfolded?  Is…

A: Accumulation of misfolded proteins cause disease various neurodegenerative diseases, such as amyloid…

Q: Cystic fibrosis is genetic disease caused by mutations in the CFTR gene. The consequence of this is…

A: As per the honor code, we cannot provide you any third party link. we have solved the rest of the…

Q: Discuss the key factors & mechanisms during co-translational translocation by which START TRANSFER…

A: INTRODUCTION co translational translocation Co-translational translocation of a protein means the…

Q: Cystic fibrosis is genetic disease caused by mutations in the CFTR gene. The consequence of this is…

A: Cystic fibrosis is a recessive disease in which both the copies of the gene must be mutated to cause…

Q: • Description of Phenylketonuria  • Explanation of what causes Phenylketonuria  • Explanation of the…

A: A) Phenylketonuria additionally called PKU, is an uncommon acquired disorder that makes an amino…

Q: In Cystic Fibrosis, what are the normal and mutated protein function

A: Cystic fibrosis is an autosomal recessive genetic disorder which affects the lungs and also the…

Q: Protein modifications occurring in the Golgi apparatus include:  removal of sialic acid…

A: Introduction: Golgi apparatus is membrane-bound organelles that are sac-like present in the…

Q: Many neurodegenrative diseases are thought to be caused by increased levels of unfolded proteins.…

A: Neurodegenerative diseases are caused by the accumulation of misfolded proteins. Examples of…

Q: Given that a faulty ribosomal protein is the culprit and causes DBA, discuss the possible role of…

A: The bone marrow does not create sufficient red blood cells to carry oxygen across the body in cases…

Q: Explain the genetic alterations resulting in protein synthesis defects and their relationship to…

A: In genetics, the genetic alterations is defined as the abnormalities that is caused due to the…

Q: Please describe the enzyme - mediated reactions required for a histidine, freely floating in the…

A: Histidine is a amino acid which is used in protein biosynthesis. The biosynthesis of histidine…

Q: Cystic fibrosis is genetic disease caused by mutations in the CFTR gene. The consequence of this is…

A: Cystic fibrosis is a rare genetic disorder that occurs when there is an inherited mutation in cystic…

Q: The post-translational modification called collagen (one word = noun) is essential in the…

A: In living organisms, all the physiological and biochemical actions are performed by the appropriate…

Q: You are a brilliant (but evil) biochemist who is developing a toxin that can be used to paralyze…

A: The loss of muscle function to a part of the body or whole body itself may be caused by cerebral…

Q: In eukaryotic cells secreted proteins are targeted first to the endoplasmic reticulum and then pass…

A: Cell is basic structural and functional unit of life which forms all the tissues and organs of human…

Q: Silent mutations that occur in DNA are quite common in living cells and usually involve no effects…

A: A silent mutation is a change in the sequence of nucleotide bases that constitutes DNA, without a…

Q: Cystic fibrosis is genetic disease caused by mutations in the CFTR gene. The consequence of this is…

A:

Q: Familial hypercholesterolemia is a genetic condition characterized by an absence of functional LDL…

A: About 1 in 100 to 200 people have mutations in the LDLR gene that encodes the LDL receptor protein,…

Q: As we focused on the genetic code and the transcription of genetic information stored in DNA into…

A: Introduction: Splicing is a process where non-coding sequences of an m-RNA is removed from the…

Q: The tumor suppressor pRB also binds to and suppresses theactivity of retinoblastoma binding protein…

A: The segments of the genetic material which helps in the expression of the characters are known as…

Q: If Dr. Aikenhed wanted to see if there was mutation within the protein-coding sequence of the gene…

A: The technique which can be used to compare protein-coding sequence i.e the nucleotide sequence of…

Q: True or false: In the ribosome, a protein enzyme is responsible for connecting the two amino acids…

A: The mechanism of synthesis of protein is known as the translation that takes place in the cytoplasm…

Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.