Assume that during the process of creating the SHH protein an error was made. Instead of producing a 462-amino-acid-long protein, you only make a 20-amino-acid-long protein. Assume the error is detected in the Golgi apparatus. Will this protein be exported into the extracellular space? If your answer is no, what will happen to this protein?
Assume that during the process of creating the SHH protein an error was made. Instead of producing a 462-amino-acid-long protein, you only make a 20-amino-acid-long protein. Assume the error is detected in the Golgi apparatus. Will this protein be exported into the extracellular space? If your answer is no, what will happen to this protein?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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- Assume that during the process of creating the SHH protein an error was made. Instead of producing a 462-amino-acid-long protein, you only make a 20-amino-acid-long protein. Assume the error is detected in the Golgi apparatus. Will this protein be exported into the extracellular space? If your answer is no, what will happen to this protein?
![NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE
Organelles in Concert:
Modeling the Coordination of Cell Structures
by
Alexandra V. Tremblay
Department of Biology
University of North Georgia, Dahlonega, GA
Sonic Hedgehog Protein Synthesis
After completing this activity, you should be able to describe the function(s) and spatial arrangement of each organelle within the
cell and be able to describe the coordination among the organelles necessary for cellular function.
Background:
Sonic Hedgehog protein (SHH) is an essential 462 amino acid protein produced in vertebrates during the early stages of
embryonic development [1]. The protein is encoded by the shh gene, which in humans is located on chromosome 7 [2]. The SHH
protein that is produced by this gene is called a "morphogen," or chemical agent that drives morphological changes in an
organism. After synthesis, a cholesterol molecule is added to the C-terminal end of the amino acid sequence, and SHH is
secreted by the cell into the extracellular space [3]. Once SHH is outside the cell, it forms a concentration gradient that promotes
the development of several types of specialized tissue including the brain, spinal cord, and limbs and digits in vertebrates [4].](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F8bce45ac-d4bb-4c39-ab64-6aff595f666a%2F39b9352b-c253-40e5-9075-5aff4b1cf288%2Fet4ma4_processed.png&w=3840&q=75)
Transcribed Image Text:NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE
Organelles in Concert:
Modeling the Coordination of Cell Structures
by
Alexandra V. Tremblay
Department of Biology
University of North Georgia, Dahlonega, GA
Sonic Hedgehog Protein Synthesis
After completing this activity, you should be able to describe the function(s) and spatial arrangement of each organelle within the
cell and be able to describe the coordination among the organelles necessary for cellular function.
Background:
Sonic Hedgehog protein (SHH) is an essential 462 amino acid protein produced in vertebrates during the early stages of
embryonic development [1]. The protein is encoded by the shh gene, which in humans is located on chromosome 7 [2]. The SHH
protein that is produced by this gene is called a "morphogen," or chemical agent that drives morphological changes in an
organism. After synthesis, a cholesterol molecule is added to the C-terminal end of the amino acid sequence, and SHH is
secreted by the cell into the extracellular space [3]. Once SHH is outside the cell, it forms a concentration gradient that promotes
the development of several types of specialized tissue including the brain, spinal cord, and limbs and digits in vertebrates [4].
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