A significant number of mutations in the HBB gene that cause human b@thalassemia occur within introns or in upstream noncoding sequences. Explain why mutations in these regions often lead to severe disease, although they may not directly alter the coding regions of the gene.

Q: Introns in eukaryotic protein-coding genes are rarely shorter than 65 nucleotides in length. What…

A: In eukaryotes the template strand of DNA gets transcribed into pre-mRNA by the process known as…

Q: The following is the only intron sequence of a gene that will be excised during the maturation of…

A: RNA splicing is the process of removal of non coding sequences called as introns and joining of…

Q: Consider the Rho-dependent terminator sequence 5’CCCAGCCCGCCUAAUGAGCGGCCUUUUUUUU-3’. What affect…

A: The mutation is the change in the nucleotide sequence of the DNA. The point mutation is the mutation…

Q: by Transcription Factor IID (TF IID)

A:

Q: Introns in eukaryotic protein-coding genes may be quite large, but almost none are smaller than…

A: An intron is any nucleotide sequence within a gene that is removed by RNA splicing during maturation…

Q: Most of the mutations that Yanofsky recovered were missense mutations. However, Yanofsky also…

A: Hypothesis is basically a proposed explanation for any naturally occurring phenomenon in the…

Q: A certain ochre suppressor inserts glutamine in response to the ochre codon. What is the most likely…

A: In this scenario, where a suppressor mutation allows the insertion of glutamine instead of…

Q: Hemophilia in the Russian royal family was caused by defective protein involved in blood clotting…

A: Genetic mutations can generate a PTC and elicit NMD in several ways: directly by generating a…

Q: Some DNA nucleotides are located within the coding regions of genes, where they specify the amino…

A: When transcription activator proteins bind to the regulatory promoter sequences of gene, they…

Q: Here is a second human gene, called cxx3. The structure indicates the following: the start and end…

A: RT-PCR (Reverse Transcription Polymerase Chain Reaction) is a molecular technique commonly used to…

Q: . The human gene for ß2 lens crystallin has the components listed below. The numbers represent…

A: Since we only answer up to 3 sub-parts, we’ll answer the first three. Please resubmit the question…

Q: Tay Sachs disease is an autosomal recessive disease in which a protein – Hex A - is abnormal. To…

A: Molecular Biology is the branch of biology that deals with a study of the composition, arrangement,…

Q: The following is the only intron sequence of a gene that will be excised during the maturation of…

A: In science, a gene is an essential unit of heredity and a succession of nucleotides in DNA or RNA…

Q: The Dscam locus in Drosophila melanogaster has 24 exons. Four of these exons are able to undergo…

A: Alternative splicing results in several products being made from one chromosome. In higher…

Q: The protein encoded by the cystic fibrosis gene is 1480amino acids long, yet the gene spans 250 kb.…

A: Because the gene contains introns (non-coding regions within the gene) that are removed during the…

Q: What molecular biology strategy can best be used to determine Inhibition of the splicing of one…

A: In eukaryotic genes, introns exist. They are interstitial sequences (80-10,000 bp). They do not code…

Q: The SARS-CoV-2 genome has a cap at its 5'-end that is the same as the one seen on most human mRNA…

A:

Q: Hemophilia in the Russian royal family was caused by defective protein involved in blood clotting…

A: Hemophilia -- It occurs in about 1 of every 5000 males .     Usually a inherited disorder in which…

Q: The entire genome of the yeast Saccharomyces cerevisiae has been sequenced. This sequencing has led…

A: The entire genome of the yeast has been sequenced and open reading frames (sequences with…

Q: Inhibitors for this reverse transcriptase fall in two classes: nucleoside analog inhibitors (NRTIs)…

A: Reverse transcriptase is an enzyme that synthesizes DNA from RNA. Reverse transcriptase catalyzes…

Q: The 5′ region of the TPP riboswitch in Bacillus subtilis is very similar to the TPP riboswitch in E.…

A: Bacterias are genetically regulated by RNA, they use a ribonucleic acid sequence encoded within mRNA…

Q: A gene contains eight sites where alternative splicing is possible. Assuming that the splicing…

A: Given :  A gene contains eight sites where alternative splicing is possible. To find : The splicing…

Q: The E. coli genome contains approximately 4639 kb. (a) How many copies of the 6-bp recognition…

A: E.coli is a type of bacteria that normally lives in the intestine. It is also found in the gut of…

Q: Some eukaryotic mRNAs have an AU-rich element in the 3′ untranslated region. What would be the…

A: The 3’ UTR is the untranslated region in the mRNA that follows the termination codon of translation.…

Q: Consider a single base insertion mutation between the 3rd and 4th codons in a natural gene that…

A: Amino acid  The building blocks of proteins. The protein is a polymer made up of chain of amino…

Q: You sequence the TBX1 gene from patients to diagnose if they have DiGeorge syndrome, and you find…

A: A chromosomal disorder where a small segment of 22 chromosomes is deleted. It is also an…

Q: Would a gain of function mutaion that occurs in the first exon of a gene with twelve exons more…

A: Gain-of-function type of mutation is a mutation in which the altered gene product possesses a new…

Q: The IMD2 promoter contains three upstream transcription start sites (TSS) that are utilized under…

A: Inosine monophosphate dehydrogenase (IMD2) is a key enzyme in the purine biosynthesis pathway that…

Q: Exon E10 E15 ..... .... RNA (protein) N Give TWO explanations as to how widely separated parts of a…

A: Exon are basically the functional parts of a gene which code for a functional protein. On the other…

Q: Select the three post-transcriptional modifications often seen in the processing of mRNA in…

A: 5'-capping; 3'-poly(A) tail addition; splicing

Q: There is a situation in which a gene has five exons. Please draw four possible mature products of…

A: Alternative splicing is a biological process that involves the joining of exons from the same gene…

Q: A particular type of anemia in humans, called b-thalassemia,results from a severe reduction or…

A: A disease is a state of unhealthiness of the physical body, mind and social interaction. A disease…

Q: The following is the only intron sequence of a gene that will be excised during the maturation of…

A: Prokaryotes have simpler cellular organization and gene structure when compared to eukaryotes.…

Q: If a nonsense mutation can be suppressed by a tRNA mutation that changes an anticodon so that a…

A: Mutations are defined by any changes in the original DNA sequence caused due to insertions,…

Q: Hemophilia in the Russian royal family was caused by defective protein involved in blood clotting…

A: Nonsense mutations occur when a premature nonsense or stop codon is introduced in the DNA sequence.…

Q: A mutation in the first intron of the Minnie gene gives rise to a shorter, truncated form of the…

A: Transcription is the process by which genetic information encoded in DNA is converted into a…

Q: Explain why inserting 5 bp of DNA at the –50 position of a eukaryotic gene decreases the rate of RNA…

A: The process of transcription occurs in the nucleus, during which RNA molecule is synthesized from…

Q: = exons = introns Transcription termination site (also poly A site) Promoter Start of transcription…

A: Transcription is the process which consists of several steps of DNA-based gene expression. Here a…

Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.