Briefly discuss (referring to the images provided) why mutant 2 fails to produce functional protein. Note that none of the mRNA transcribed from this gene is of the expected size; some of the mRNA molecules produced are 223 nucleotides shorter than expected, whilst others are 47 nucleotides longer than expected.
Briefly discuss (referring to the images provided) why mutant 2 fails to produce functional protein. Note that none of the mRNA transcribed from this gene is of the expected size; some of the mRNA molecules produced are 223 nucleotides shorter than expected, whilst others are 47 nucleotides longer than expected.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
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Question
Briefly discuss (referring to the images provided) why mutant 2 fails to produce functional protein. Note that none of the mRNA transcribed from this gene is of the expected size; some of the mRNA molecules produced are 223 nucleotides shorter than expected, whilst others are 47 nucleotides longer than expected.
Transcribed Image Text:CDNA sequence from gene A
>CDNA
АСАТTTGCTTтсTGACACAACТСTGТТСАСТAGCAACСТСАААСAGACACCАTGGTGCATCTGAСТССТGAGGAGA
AGTCTGCCGTTACTGCCCTGTGGGGCAAGGTGAACGTGGATGAAGTTGGTGGTGAGGCCCTGGGCAGGCTGCTGG
TGGTCTACCСТTGGACCCAGAGGTTCTTTGAGTCCTTTGGGGATCTGTССАСТССТGATGCTGTTATGGGCAACC
CTAAGGTGAAGGCTCATGGCAAGAAAGTGCTCGGTGCCTTTAGTGATGGCCTGGCTCACCTGGACAACCTCAAGG
GCACCTTTGCCACACTGAGTGAGCTGCACTGTGACAAGCTGCACGTGGATCCTGAGAACTTCAGGCTCCTGGGCA
ACGTGCTGGTCTGTGTGCTGGCCCATCАСТТTGGCAAAGAATTCACСССАССАGTGCAGGCTGCСТАТСАGAAAG
TGGTGGCTGGTGTGGCTAАTGCCCTGGСССАСААGTAТСАСТААGCТCGCTTTСТTGCTGTCCAAТТТСТАТТАА
AGGTTCCTTTGTTCCCTAAGTCCAACTACTAAACTGGGGGATATTATGAAGGGCCTTGAGCATCTGGATTCTGCC
ΤAAΤAAAAACAΤΤΤATTTTCATTGCAA
Transcribed Image Text:Chromosomal DNA sequence from gene A
>chromosomal
АСАТTTGCTТСTGACACAAСTGTGTTCACТAGCAACСТСАААСАGACAССАTGGTGCAТСТGАСТССТGAGGAGA
AGTCTGCCGТТАСTGCCСTGTGGGGCAAGGTGAACGTGGATGAAGTTGGTGGTGAGGCССTGGGCAGGTTGGTAT
САAGGTTACАAGACAGGTТТАAGGAGACСААТАGAAAСTGGGCATGTGGAGACAGAGAAGACTCTTGGGTTTCTG
АTAGGCACTGACTCТСТСТGCCТАТТGGTСТАТТТТСССАСССТТАGGСTGCTGGTGGТСТАСССТТGGACCCAG
AGGTTCTTTGAGTCCTTTGGGGATCTGTCСАСТССТGATтGCTGTTATGGGCAACCCTАAGGTGAAGGCТСАТGGC
AAGAAAGTGCTCGGTGCCТТTAGTGATGGCCTGGCTCАССTGGACAАССТСААGGGCACCTTTGCСАСАСТGAGТ
GAGCTGCACTGTGACAAGСTGCACGTGGATCCTGAGAАСТТСАGGGTGAGTCTATGGGACGCTTGATGTTTTCTТ
ТССССТТСТТTТСТАТGGТТАAGTTCATGTCATAGGAAGGGGATAAGTAACAGGGTАСAGTTTAGAATGGGAAAС
AGACGAATGATTGCATCAGTGTGGAAGTСТСAGGATCGTTTTAGTTТСТТТТАТТТGCTGTTCATААСААТТGTТ
TТСТТTTGTТТААТТСТТGCTTTCTTTTTTTTTСTТCТСCGCAATTТTТАСТАТТАТАСТТААТGССТТААСАТТ
GTGTATAACАААAGGAAAТАТСТСТGAGATACATTAAGTAACTTАAAAAAAAАСТТТАСАСAGTCTGCСТAGTAС
ΑΤTACΤΑΤΤTGGAATATATGTGΤGCTTAΤTTGCAΤΑΤ TCAΤAATCTCCCTACTTTATΤTTCTTΤ ΤATTTTAAT Τ
GATACΑΤAAT CAT TATACATAT ΤΤATGGGTTAAAGTGTAATGTTTΑΑΤΑΤGTGTACACATAT T GAC CAAATCAG
GGTAATTTT GCATTTGTAAΤΤΤTAΑAAAT GCTTTCTTCTTTTAΑΤΑTACTTTTTTGTTTATCTTATTTCTAATA
СТТТСССТААТСТСТТТСТТТСAGGGCAАТААТGATAСААТGTATСАTGCСТСТТТGCACCATTCТАААGAATAА
СAGTGATAAТТТСTGGGTТАAGGCAATAGCAATATСTСTGCАTАТАААТАТТТСТGCATATAAATTGТAАСТGAТ
GTAAGAGGTTТСАТАТТGСТААТАGCAGCTACAАТССAGCTАCСАTТСTGСTTТТАТТTТАTGGTTGGGATAAGG
СTGGATTATТСTGAGTCCАAGCTAGGCCСТТТTGCTААТСАТGTTCАТАССТСТТАТСТТССТСССАСAGCTCСТ
GGGCAACGTGCTGGTCTGTGTGCTGGCCCАТСАСТТТGGCAAAGAATTСАССССАССАGTGCAGGCTGCCTAТCА
GAAAGTGGTGGCTGGTGTGGCTAАТGCCCTGGCCCACAGTATCАСТАAGCTCGCTTTСТTGCTGTCCААТТТСТ
АТТААAGGTТССТТTGTTСССТААGTCСААСТАСТАААСTGGGGGAТАТТАТGAAGGGCCTTGAGCATСTGGATТ
CTGCCΤAΑΤΑΑΑAAACAΤTTATTTCAT TGCAA
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