(A) HUMAN a-TROPOMYOSIN GENE 5 6 910 23 78 11 12 13 (B) FOUR DIFFERENT SPLICE VARIANTS Figure Q6-3 Alternatively spliced MRNAS from the human a-tropomyosin gene (Problem 6-8). (A) Exons in the human a-tropomyosin gene. The locations and relative sizes of exons are shown by the blue and red rectangles, with altenative exons in red. (B) Splicing patterns for four a-tropomyosin MRNAS. Splicing is indicated by lines connecting the exons that are included in the MRNA.
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
The human α-tropomyosin gene is alternatively
spliced to produce different forms of α-tropomyosin
mRNA in different cell types (Figure Q6–3). For all forms of
the mRNA, the protein sequences encoded by exon 1 are
the same, as are the protein sequences encoded by exon
10. Exons 2 and 3 are alternative exons used in different
mRNAs, as are exons 7 and 8. Which of the following state-
ments about exons 2 and 3 is the most accurate? Is that
statement also the most accurate one for exons 7 and 8?
Explain your answers.
A. Exons 2 and 3 must have the same number of
B. Exons 2 and 3 must each contain an integral num-
ber of codons (that is, the number of nucleotides divided
by 3 must be an integer).
C. Exons 2 and 3 must each contain a number of
nucleotides that when divided by 3 leaves the same
remainder (that is, 0, 1, or 2).
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