Calculate ΔGinward. Is energy required for transport to happen? The internal pH of a lysosome= 4.0 and the pH of the cytosol is 7.0. For a cell at 25°C with a -40 mV lysosome membrane potential. What is the ΔGinward for the proton gradient into the lysosome?
Calculate ΔGinward. Is energy required for transport to happen?
The internal pH of a lysosome= 4.0 and the pH of the cytosol is 7.0. For a cell at 25°C with a -40 mV lysosome membrane potential. What is the ΔGinward for the proton gradient into the lysosome?
The amount of change in free energy i.e. change in Gibbs free energy for the transport of an ion across a membrane can be quantified. This energy is factored by 2 components ; the concentration gradient( also called chemical gradient) and electrical gradient of the ion .The combination of these two gradients is what we call as the electrochemical gradient.
First we need to calculate the ion (H+) concentration on either parts of the membrane (the lysosomal membrane).
is the Gibbs free energy of transport of protons (H+) from cytosol to inside of lysosomes, through the lysosomal membrane.
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