a. The Kreb's Cycle can be divided into two stages. In one stage, carbon atoms are added and removed. In the second stage, oxaloacetate is regenerated. Considering what this means, what is the name of the intermediate molecule that begins Stage 2? Explain why you think so. b. You learned relevant chemical reactions before seeing them applied as biochemical reaction strategies. Where in the Kreb's cycle do the following classes of reactions occur? i. The "Hydration of an Alkene" is applied as is converted Molecule names go on the lines to ii. The "Oxidation of a secondary alcohol" is applied as is converted to and again as is converted to
a. The Kreb's Cycle can be divided into two stages. In one stage, carbon atoms are added and removed. In the second stage, oxaloacetate is regenerated. Considering what this means, what is the name of the intermediate molecule that begins Stage 2? Explain why you think so. b. You learned relevant chemical reactions before seeing them applied as biochemical reaction strategies. Where in the Kreb's cycle do the following classes of reactions occur? i. The "Hydration of an Alkene" is applied as is converted Molecule names go on the lines to ii. The "Oxidation of a secondary alcohol" is applied as is converted to and again as is converted to
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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
Transcribed Image Text:a. The Kreb's Cycle can be divided into two
Transformation of pyruvate into acetyl Con
stages. In one stage, carbon atoms are added
Caro
and removed. In the second stage,
CO,
Two
oxaloacetate is regenerated. Considering what
(inter
Pyruvato
this means, what is the name of the
intermediate molecule that begins Stage 2?
The Krebs/citric acid cycle
CH -0
Explain why you think so.
CO0
Acetyl
Coo
NADH C.
HO-CH
CH
NAD+
Oxaloece
Coo
Malate
CH
HC
Fumarate
Co0
FADH
FAD succinate
b. You learned relevant chemical reactions
before seeing them applied as biochemical
CH
CH
reaction strategies. Where in the Kreb's cycle
do the following classes of reactions occur?
iii. An acyl-group transfer
cycle. The first time wher
The "Hydration of an Alkene" is applied as
COA is replaced with OH
deprotonated to COO-).
is converted
when the -SCOA comes c
Molecule names go on the lines
replaced by
actually see in the imag
comes from, it just appe
to
ii.
The "Oxidation of a secondary alcohol" is
carbons to keep track o
applied as
is
iv. What makes the con
converted to
a carbon dioxide mole
the two structures (RC
your answer.
and again as
is converted
to

Transcribed Image Text:CO2
Iragment
(interinediary)
to slaction
transport
chain
CH
Pyruvate
-Krebs/citric acid cycle
COA
COO
CH C - S
CH2
HO C CO"
CH2
Acetyi CoA
CH
COO
CH2
HS-COA
H0-CH
NADH
HC
CH2
NAD+
Oxaloacetate
Citrate
HO-CH
Isocitrate
NAD+
Malate
NADH
CO
H20-
CH
a-Ketoglutarate
CH2
HC
NAD+
Fumarate
NADH
CH2
COO
O2
FADH
FAD
Suceinyl CoA
Succinate
COO
GTP
GDP
CO"
1.
CH:
PO.
CH2
CH2
CH2
GTP
1.
S COA
GDP
COO
ADP
ATP
iii. An acyl-group transfer can be seen twice in the
cycle. The first time when -SCOA group on acetyl-
COA is replaced with OH from water (which then is
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