a. The Kreb's Cycle can be divided into two stages. In one stage, carbon atoms are added and removed. In the second stage, oxaloacetate is regenerated. Considering what this means, what is the name of the intermediate molecule that begins Stage 2? Explain why you think so. b. You learned relevant chemical reactions before seeing them applied as biochemical reaction strategies. Where in the Kreb's cycle do the following classes of reactions occur? i. The "Hydration of an Alkene" is applied as is converted Molecule names go on the lines to ii. The "Oxidation of a secondary alcohol" is applied as is converted to and again as is converted to

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
icon
Related questions
Question
a. The Kreb's Cycle can be divided into two
Transformation of pyruvate into acetyl Con
stages. In one stage, carbon atoms are added
Caro
and removed. In the second stage,
CO,
Two
oxaloacetate is regenerated. Considering what
(inter
Pyruvato
this means, what is the name of the
intermediate molecule that begins Stage 2?
The Krebs/citric acid cycle
CH -0
Explain why you think so.
CO0
Acetyl
Coo
NADH C.
HO-CH
CH
NAD+
Oxaloece
Coo
Malate
CH
HC
Fumarate
Co0
FADH
FAD succinate
b. You learned relevant chemical reactions
before seeing them applied as biochemical
CH
CH
reaction strategies. Where in the Kreb's cycle
do the following classes of reactions occur?
iii. An acyl-group transfer
cycle. The first time wher
The "Hydration of an Alkene" is applied as
COA is replaced with OH
deprotonated to COO-).
is converted
when the -SCOA comes c
Molecule names go on the lines
replaced by
actually see in the imag
comes from, it just appe
to
ii.
The "Oxidation of a secondary alcohol" is
carbons to keep track o
applied as
is
iv. What makes the con
converted to
a carbon dioxide mole
the two structures (RC
your answer.
and again as
is converted
to
Transcribed Image Text:a. The Kreb's Cycle can be divided into two Transformation of pyruvate into acetyl Con stages. In one stage, carbon atoms are added Caro and removed. In the second stage, CO, Two oxaloacetate is regenerated. Considering what (inter Pyruvato this means, what is the name of the intermediate molecule that begins Stage 2? The Krebs/citric acid cycle CH -0 Explain why you think so. CO0 Acetyl Coo NADH C. HO-CH CH NAD+ Oxaloece Coo Malate CH HC Fumarate Co0 FADH FAD succinate b. You learned relevant chemical reactions before seeing them applied as biochemical CH CH reaction strategies. Where in the Kreb's cycle do the following classes of reactions occur? iii. An acyl-group transfer cycle. The first time wher The "Hydration of an Alkene" is applied as COA is replaced with OH deprotonated to COO-). is converted when the -SCOA comes c Molecule names go on the lines replaced by actually see in the imag comes from, it just appe to ii. The "Oxidation of a secondary alcohol" is carbons to keep track o applied as is iv. What makes the con converted to a carbon dioxide mole the two structures (RC your answer. and again as is converted to
CO2
Iragment
(interinediary)
to slaction
transport
chain
CH
Pyruvate
-Krebs/citric acid cycle
COA
COO
CH C - S
CH2
HO C CO"
CH2
Acetyi CoA
CH
COO
CH2
HS-COA
H0-CH
NADH
HC
CH2
NAD+
Oxaloacetate
Citrate
HO-CH
Isocitrate
NAD+
Malate
NADH
CO
H20-
CH
a-Ketoglutarate
CH2
HC
NAD+
Fumarate
NADH
CH2
COO
O2
FADH
FAD
Suceinyl CoA
Succinate
COO
GTP
GDP
CO"
1.
CH:
PO.
CH2
CH2
CH2
GTP
1.
S COA
GDP
COO
ADP
ATP
iii. An acyl-group transfer can be seen twice in the
cycle. The first time when -SCOA group on acetyl-
COA is replaced with OH from water (which then is
Transcribed Image Text:CO2 Iragment (interinediary) to slaction transport chain CH Pyruvate -Krebs/citric acid cycle COA COO CH C - S CH2 HO C CO" CH2 Acetyi CoA CH COO CH2 HS-COA H0-CH NADH HC CH2 NAD+ Oxaloacetate Citrate HO-CH Isocitrate NAD+ Malate NADH CO H20- CH a-Ketoglutarate CH2 HC NAD+ Fumarate NADH CH2 COO O2 FADH FAD Suceinyl CoA Succinate COO GTP GDP CO" 1. CH: PO. CH2 CH2 CH2 GTP 1. S COA GDP COO ADP ATP iii. An acyl-group transfer can be seen twice in the cycle. The first time when -SCOA group on acetyl- COA is replaced with OH from water (which then is
Expert Solution
steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Metabolic diseases
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.
Similar questions
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON