(c) Based on the primary sequence surrounding the transmembrane portion, predict which Portion would likely be found on the cytoplasmic side of the membrane (if any), and which Portion (if any) would be found on the extra cellular side of the membrane according to The "inside positive" rule. Briefly justify your reasoning. (d) Predict the fragments that would be produced by digesting the 5-HT 24 Receptor protein With Trypsin. How might you use Trypsin to determine the orientation of the transmem- Brane protein?
(c) Based on the primary sequence surrounding the transmembrane portion, predict which Portion would likely be found on the cytoplasmic side of the membrane (if any), and which Portion (if any) would be found on the extra cellular side of the membrane according to The "inside positive" rule. Briefly justify your reasoning. (d) Predict the fragments that would be produced by digesting the 5-HT 24 Receptor protein With Trypsin. How might you use Trypsin to determine the orientation of the transmem- Brane protein?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Proteins
We generally tend to think of proteins only from a dietary lens, as a component of what we eat. However, they are among the most important and abundant organic macromolecules in the human body, with diverse structures and functions. Every cell contains thousands and thousands of proteins, each with specific functions. Some help in the formation of cellular membrane or walls, some help the cell to move, others act as messages or signals and flow seamlessly from one cell to another, carrying information.
Protein Expression
The method by which living organisms synthesize proteins and further modify and regulate them is called protein expression. Protein expression plays a significant role in several types of research and is highly utilized in molecular biology, biochemistry, and protein research laboratories.
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Transcribed Image Text:(c) Based on the primary sequence surrounding the transmembrane portion, predict which
Portion would likely be found on the cytoplasmic side of the membrane (if any), and which
Portion (if any) would be found on the extra cellular side of the membrane according to
The "inside positive" rule. Briefly justify your reasoning.
(d) Predict the fragments that would be produced by digesting the 5-HT 24 Receptor protein
With Trypsin. How might you use Trypsin to determine the orientation of the transmem-
Brane protein?
Transcribed Image Text:Psilocybin is rapidly de-phosphorylated in the body into psilocin, which is anagonist
For the 5-HT 24 Serotonin receptor, which binds the neurotransmitter serotonin as its natural
ligand, and acts as a ligand-gated ion channel in the central nervous system.
НО.
Serotonin
NH₂
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