The principle pathway for transport of lysosomal hydrolases from the trans-Golgi network (pH 6.6) to the late endosomes (pH 6.0) and for recycling of Mannose-6-Phosphate (M6P) receptors back to the Golgi depends on the pH difference between those two compartments. From what you know about M6P-receptor binding and recycling pathways for delivery of material to lysosomes, describe the consequences of changing the pH in those two compartments. What would happen if the pH in the trans-Golgi network was lowered to pH 6.0? choose one for each bolded answer choices in the parenthesis. Cargo proteins containing the M6P ("communication signal"/"termination signal"/ "sorting signal") would (succeed/fail) in binding efficiently to the M6Preceptor protein. The result in this case would be that lysosomal ("kinases"/"oxidoreductases"/"isomerases"/"hydrolases) would be secreted by the default pathway.
The principle pathway for transport of lysosomal hydrolases from the trans-Golgi network (pH 6.6) to the late endosomes (pH 6.0) and for recycling of Mannose-6-Phosphate (M6P) receptors back to the Golgi depends on the pH difference between those two compartments. From what you know about M6P-receptor binding and recycling pathways for delivery of material to lysosomes, describe the consequences of changing the pH in those two compartments.
What would happen if the pH in the trans-Golgi network was lowered to pH 6.0? choose one for each bolded answer choices in the parenthesis.
Cargo proteins containing the M6P ("communication signal"/"termination signal"/ "sorting signal") would (succeed/fail) in binding efficiently to the M6Preceptor protein. The result in this case would be that lysosomal ("kinases"/"oxidoreductases"/"isomerases"/"hydrolases) would be secreted by the default pathway.
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