While each G-protein subunit has a distinctly characteristic C-terminal sequence that binds certain GPCRs better than others, the GPCRs that prefer the same G-protein subunit do not share a conserved sequence motif, even in the regions that form the binding pocket for the C-terminal domain of the G-protein a subunit.  Given this fact, what must be similar about the binding pockets of these GPCRs in order to achieve specificity

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Chapter1: Biochemistry: An Evolving Science
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While each G-protein subunit has a distinctly characteristic C-terminal sequence that binds certain GPCRs better than others, the GPCRs that prefer the same G-protein subunit do not share a conserved sequence motif, even in the regions that form the binding pocket for the C-terminal domain of the G-protein a subunit.  Given this fact, what must be similar about the binding pockets of these GPCRs in order to achieve specificity?

 

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