(b) Hemoglobin is made of B-globin subunits. The first few mRNA nucleotides for B- globin are given by: (1) (ii) (iii) 5'-AUGGUCCACCUGACUCCUGAGGAGAAG...UGA-3' Write down the DNA sequence that has led to this mRNA and indicate the sense and non-sense strands and the polarity. Derive the polypeptide for the sequence using the table of the genetic code (Table Q1 below) and indicate the polarity of the polypeptide chain. A single point mutation in mRNA sequence can cause sickle cell anemia by changing the amino acid Glu to Val. For the given mRNA. indicate the point
(b) Hemoglobin is made of B-globin subunits. The first few mRNA nucleotides for B- globin are given by: (1) (ii) (iii) 5'-AUGGUCCACCUGACUCCUGAGGAGAAG...UGA-3' Write down the DNA sequence that has led to this mRNA and indicate the sense and non-sense strands and the polarity. Derive the polypeptide for the sequence using the table of the genetic code (Table Q1 below) and indicate the polarity of the polypeptide chain. A single point mutation in mRNA sequence can cause sickle cell anemia by changing the amino acid Glu to Val. For the given mRNA. indicate the point
Human Anatomy & Physiology (11th Edition)
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ISBN:9780134580999
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Chapter1: The Human Body: An Orientation
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Protein Expression
The method by which living organisms synthesize proteins and further modify and regulate them is called protein expression. Protein expression plays a significant role in several types of research and is highly utilized in molecular biology, biochemistry, and protein research laboratories.
Question
Transcribed Image Text:(b)
Hemoglobin is made of B-globin subunits. The first few mRNA nucleotides for B-
globin are given by:
(1)
(iii)
(iv)
Write down the DNA sequence that has led to this mRNA and indicate the
sense and non-sense strands and the polarity.
CE
Derive the polypeptide for the sequence using the table of the genetic code
(Table Q1 below) and indicate the polarity of the polypeptide chain.
First
Position
(5' end)
U
A single point mutation in mRNA sequence can cause sickle cell anemia by
changing the amino acid Glu to Val. For the given mRNA, indicate the point
mutations for the first Glu in the polypeptide sequence that can cause this
disease.
5'-AUGGUCCACCUGACUCCUGAGGAGAAG...UGA-3'
C
The polypeptide of B-globin contains the amino acid Leu. Write down all the
anticodons of the tRNA molecules that can potentially code for Val. Indicate
the polarity of the anti-codon.
A
G
Table 1. The Codons of the Genetic Code
Second Position
U
Phe
Phe
Leu
Leu
Leu
Leu
Leu
Leu
Ile
Ile
Ile
Met-Start
Val
Val
Val
Val
Ser
Ser
Ser
Ser
Pro
Pro
Pro
Pro
Thr
Thr
Thr
Thr
Ala
Ala
Ala
Ala
Tyr
Tyr
Stop
Stop
His
His
Gln
Gln
Asn
Asn
Lys
Lys
Asp
Asp
Glu
Glu
G
Cys
Cys
Stop
Trp
Arg
Arg
Arg
Arg
Ser
Ser
Arg
Arg
Gly
Gly
Gly
Gly
Third
Position
(3' end)
U
C
A
G
U
C
A
AGU
C
A
G
U
C
A
G
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