Part 12There have been9Part 28chromosome6significant regions identified on10· LLImage available for use under Creative Commons Attribution 2.5 Generic License. Sourced from:https://commons.wikimedia.org/wiki/File:Manhattan Plot.png12-Attribution: Ikram MK et al (2010) Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo.PLoS Genet. 2010 Oct 28;6(10):e1001184. doi:10.1371/journal.pgen.1001184.g001Based on these results, what can we claim? Select any/all that apply13different chromosomes.1415-There are at least 5 loci in the genome containing genes that influence microcirculationThe most highly associated SNP at the locus on chromosome 19 causes an increase in microcirculationA locus on chromosome 19 is the most significantly associated with differences in microcirculationLoss of function mutations in a least 5 genes contribute to variation in microcirculation This question has two parts.Below is a Manhattan plot from a GWAS investigating microcirculation (circulation of blood through the smallest bloodvessels). Changes in microcirculation can be correlated to increased risk of cardiovascular events. For our purposes we willconsider the -log10(P) of about 7 as the significance threshold.1510- log10 (P)2Part 138chromosome6- OL·LLĮImage available for use under Creative Commons Attribution 2.5 Generic License. Sourced from:https://commons.wikimedia.org/wiki/File:ManhattanPlot.pngAttribution: Ikram MK et al (2010) Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo.PLoS Genet. 2010 Oct 28;6(10):e1001184. doi:10.1371/journal.pgen.1001184.g001

In the provided Manhattan plot, regions with -log10(P) values exceeding 7 are considered…

Based on these results, what can we claim? Select any/all that apply O There are at least 5 loci in the genome containing genes that influence microcirculation The most highly associated SNP at the locus on chromosome 19 causes an increase in microcirculation A locus on chromosome 19 is the most significantly associated with differences in microcirculation O Loss of function mutations in a least 5 genes contribute to variation in microcirculation

Based on these results, what can we claim? Select any/all that apply O There are at least 5 loci in the genome containing genes that influence microcirculation The most highly associated SNP at the locus on chromosome 19 causes an increase in microcirculation A locus on chromosome 19 is the most significantly associated with differences in microcirculation O Loss of function mutations in a least 5 genes contribute to variation in microcirculation

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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