(b) Assign the priorities (as either high and low, or 1 and 2) for the groups of the alkene. Based on those assigned priorities, predict the configuration (E or Z). Include the priority directly adjacent to the corresponding group. -Br OH
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Assign the priorities (as either high and low, or 1 and 2) for the groups of the alkene.
Based on those assigned priorities, predict the configuration (E or Z). Include the priority directly
adjacent to the corresponding group.
-Br
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- Stereochemistry The alkyl bromide below can undergo an E2 but not in its shown conformation. Draw the conformer (as a line drawing, not a Newman projection) out of which an E2 elimination can occur, with all bonds/groups in the original drawing included. 'Bu = tert-butyl H3C H H3C Br tBu alkyl bromide (b) Draw the alkene formed in the E2 elimination reaction of this alkyl bromide promoted by potassium tert-butoxide (KOtBu). (c) Indicate if this E2 elimination reaction is stereospecific or stereoselective (write or circle stereospecific or stereoselective) Regioselectivity (d) Two potential products can form in the following E2 elimination promoted by KOtBu. Circle the major alkene product. (e) KOtBu H3C H3C Indicate if the reaction in (d) is under kinetic control or thermodynamic control. (write or circle kinetic or thermodynamic control) 5Draw the structure of (Z)-4-methyl-2-pentene. • Consider E/Z stereochemistry of alkenes. You do not have to explicitly draw H atoms. opy aste ChemDoodleAssign priorities to these set of Substituents (in assigning priority write numbers 1,2,3,4 below the structure of the molecules on the space given). Give explanation.
- Draw the major organic product(s) for the following reactions, including stereochemistry when appropriateẞ-Eliminations that follow an E2 mechanism have stereochemical implications that need to be addressed. Elimination MUST occur from a conformation with an "anti periplanar" between the leaving group and ẞ-hydrogen. This corresponds to a staggered conformation in acyclic systems and "trans-diaxial" in cyclohexane chairs. A. Examples of acyclic systems H CH3 Et NaOCH3 H3C7 Et Br CHOOS Br H CH3 Ph NaOH 13 H t-Bu HH Br NaOH Ph Ph H 1 HOOGMUsing the Cahn-Ingold-Prelog sequence rules, assign configurations to EACH of the alkenes (A-D) .as E or Z Write your answers in the box below CH3 CH,CH2OH CH2CH3 H3C H3CO CD CH3 Br D.
- B. Describe the stereochemistry (with structures) of the addition of Br2 and H₂O to cyclohexene. C. Arrange the following ions by increasing basicity, where 1 is the most basic and 5 is the least. HCEC CH3CH3NH2 CH3CH₂O CH3CH₂ H₂C=CH1. Elimination reactions and principles of reactivity Stereochemistry (a) The alkyl bromide below can undergo an E2 but not in its shown conformation. Draw the conformer (as a line drawing, not a Newman projection) out of which an E2 elimination can occur, with all bonds/groups in the original drawing included. 'Bu = tert-butyl H3C H&C H Br H tBu alkyl bromide (b) Draw the alkene formed in the E2 elimination reaction of this alkyl bromide promoted by potassium tert-butoxide (KOtBu). (c) Indicate if this E2 elimination reaction is stereospecific or stereoselective (write or circle stereospecific or stereoselective)How would the HNMR of these two compounds be different when taking into account the stereochemistry? H. ;c= H₂C-CH₂ н-с нас-нас H (2)-isomer ~-CH₂-CH₂-OH -CH₂-CH₂-OH (E)-isomer
- Considering both 5-methylcyclopenta-1,3-diene (A) and 7-methylcyclohepta-1,3,5-triene (B), which labeled H atom is most acidic?Which labeled H atom is least acidic? Explain your choices.See attached imageAssign the stereochemical configuration (E or Z) for the alkene below. Show your work, indicating clearly which groups are assigned high priority (e.g., through assigning the groups numbers, circling only the high priority groups, or labeling groups as high or low).
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