4) (2 pts.) This is a "retrosynthesis" problem. Identify the TWO MOLECULES necessary to prepare theamine shown below via reductive amination.CN-CH₂N.CH3

Step 1:Two ways are possible 1) way with one molecule 2) way two molecules Step 2:Answer is 2) way…

Answered: 4) (2 pts.) This is a "retrosynthesis"…

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter23: Amines

Section: Chapter Questions

Problem 23.51P

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Similar questions

Maraviroc, a drug used to treat HIV, is prepared by reductive amination of aldehyde A with amine B. What is the structure of maraviroc, if the most basic N atom of amine B is used in reductive amination?
4) This is a "retrosynthesis" problem. Identify the TWO MOLECULES necessary to amine shown below via reductive amination. a NH
Rank the following compounds in order of increasing basicity.
Rank the following compounds in order of increasing basicity in aqueous solution, least basic first a) Propylamine, ammonium, dipropylamine b) Methyl-3-aminopropanoate, sectutylamine, NH3*CH2CH2NH2 c) Aniline, methyl m-aminobenzoate,, methy! p-aminobenzoate
k Please don't provide handwritten solution
B) Rank the following compounds toward increasing acidity, why? 2) 1,3-benzoqounoin 2)cyclohexanoic acid 3)cyclohexanal 4) cyclohexanol
3. For the following amines, propose a stepwise synthesis for each compound. ? a) b) ? OH ZH NH₂ 4. Imidazole has two nitrogen atoms, labeled as N3 and N1. Please indicate which nitrogen is more basic, Draw the products of protonating both nitrogen atoms and
(d) When a primary amine is combined with a ketone, both an imine and an enamine can be obtained. With most ketones, the major product is the imine, as shown: H3C NH2 -N -CH3 -CH3 imine: major product enamine: minor product However, in some cases, like the one shown below, the major product is the enamine. CO₂Et CO₂Et CO₂Et H H3C NH2 -CH3 imine: minor product -CH3 enamine: major product Referring to specific features of the starting materials, intermediates, or products, explain why.
(3) Propose how to obtain following amine from given starting material. More than one step may be required. Provide all reagents needed for each step and product after each step. gor ~ from
Rank the following amines based on basicity Rationalize the electronic effects responsible for the basicity of amines
6. Draw the products formed upon Hofmann Elimination of the two isomeric amines below. (Excess CH3-I and K₂CO3 then Ag₂O) of NH₂
( -NH NH Identify the Bronsted base in the following reaction of I and II shown below. НО 11 CF₂ CF₁ A) compound I B) compound II

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4) (2 pts.) This is a "retrosynthesis" problem. Identify the TWO MOLECULES necessary to prepare the amine shown below via reductive amination. CN-CH₂ N. CH3