Answer questions 14-15 based on the following scenario: BuzzLight is an illegal substance given to racing dogs before a race. When tested in dogs by IV injection, the time-plasma concentration and time- response relationships were determined over a 3 hour period -> 14. Which of the following factors could account for the observed duration of action? a) Site of action outside the blood b) BuzzLight is a P-glycoprotein pump inhibitor c) BuzzLight is a prodrug d) a & b e) a & c Plasma drug concentration Plasma- concentration curve 100 Intensity of effect-time curve BO Time 60 50 % Maximum response 20 20 15. Cats responded similarly to IV treatment but mice did not respond. In mice, plasma concentration diminished more slowly than in dogs and cats, and higher concentrations were found unchanged in mouse urine. Which of the following factors most likely accounts for this observation? a) BuzzLight is a prodrug b) BuzzLight acts as a partial agonist in mice but a complete agonist in dogs c) Mice metabolize BuzzLight more quickly than dogs d) Interspecies variation in the rate of BuzzLight absorption e) All of the above
Answer questions 14-15 based on the following scenario: BuzzLight is an illegal substance given to racing dogs before a race. When tested in dogs by IV injection, the time-plasma concentration and time- response relationships were determined over a 3 hour period -> 14. Which of the following factors could account for the observed duration of action? a) Site of action outside the blood b) BuzzLight is a P-glycoprotein pump inhibitor c) BuzzLight is a prodrug d) a & b e) a & c Plasma drug concentration Plasma- concentration curve 100 Intensity of effect-time curve BO Time 60 50 % Maximum response 20 20 15. Cats responded similarly to IV treatment but mice did not respond. In mice, plasma concentration diminished more slowly than in dogs and cats, and higher concentrations were found unchanged in mouse urine. Which of the following factors most likely accounts for this observation? a) BuzzLight is a prodrug b) BuzzLight acts as a partial agonist in mice but a complete agonist in dogs c) Mice metabolize BuzzLight more quickly than dogs d) Interspecies variation in the rate of BuzzLight absorption e) All of the above
Basic Clinical Laboratory Techniques 6E
6th Edition
ISBN:9781133893943
Author:ESTRIDGE
Publisher:ESTRIDGE
Chapter3: Basic Hemostasis
Section3.4: Prothrombin Time
Problem 14RQ
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Question
Transcribed Image Text:Answer questions 14-15 based on the following scenario:
BuzzLight is an illegal substance given to racing
dogs before a race. When tested in dogs by IV
injection, the time-plasma concentration and time-
response relationships were determined over a 3
hour period ->
14. Which of the following factors could account
for the observed duration of action?
a) Site of action outside the blood
b) BuzzLight is a P-glycoprotein pump inhibitor
c) BuzzLight is a prodrug
d) a & b
e) a & c
Plasma drug concentration
Plasma-
concentration
curve
100
Intensity of
effect-time curve
BO
Time
60
50
% Maximum response
20
20
15. Cats responded similarly to IV treatment but mice did not respond. In mice, plasma concentration
diminished more slowly than in dogs and cats, and higher concentrations were found unchanged in
mouse urine. Which of the following factors most likely accounts for this observation?
a) BuzzLight is a prodrug
b) BuzzLight acts as a partial agonist in mice but a complete agonist in dogs
c) Mice metabolize BuzzLight more quickly than dogs
d) Interspecies variation in the rate of BuzzLight absorption
e) All of the above
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