A lack of the enzyme glucose 6-phosphatase is one of the causes of the glycogen storage disorder von Gierke disease.Predict three signs or symptoms of von Gierke disease.hyperlipidemia (high lipid concentration in blood)normal glycogen structure, with very large amounts present in livercirrhosis of the liverincreased amounts of lactate and pyruvate in bloodmuscle cramps

Glucose 6-phosphatase is an enzyme that plays a crucial role in the glucose metabolism. It is…

Answered: A lack of the enzyme glucose…

Nutrition Now

8th Edition

ISBN:9781337415408

Author:Brown

Publisher:Brown

Chapter12: Useful Facts About Sugars, Starches, And Fiber

Section: Chapter Questions

Problem 15RQ

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Deficiencies of carnitine, carnitine acyltransferases, or carnitine/acylcarnitine translocase affect the metabolism of long-chain fatty acids. Many of the symptoms are similar, and include hypoketotic hypoglycemia, low ketone levels and low blood sugar with fasting, and damage to the liver, heart, or muscles due to fatty acid buildup in those tissues. Symptom severity varies with the form of the deficiency. The following abbreviations are used: carnitine acyltransferase (carnitine palmitoyltransferase), CPT and carnitine/acylcarnitine translocase, CACT. Identify each symptom or effect as a deficiency of CPT I, CPT II, or CACT. CPT I deficiency CPT II deficiency CACT deficiency Answer Bank acyl carnitine not transported into mitochondrial matrix long-chain fatty acids not transferred to carnitine long-chain fatty acids remain attached to carnitine in matrix
Indicate the following where the tissue(s) for the metabolic pathway takes place: Glycogenesis Lipogenesis Glycogenolysis Lipolysis Gluconeogenesis
Describe five possible fates for glucose 6-phosphate in the liver.
A stroke is caused by blocking the blood supply to the brain. What is the major end-product of glucose catabolism in brain cells during a stroke? Lactate Acetaldehyde Pyruvate Carbon dioxide Acetyl coenzyme A
Given the following glycogen storage diseases, predict the effects of each disease on the amount of liver glycogen stored and the blood glucose levels. (i) Von Gierke disease, defective enzyme: glucose 6-phosphatase (ii) Hers's disease, defective enzyme : liver phosphorylase
In 3-4 sentences, briefly explain how lactate is formed, the biological effect of lactate, and explain the biochemical process and path for conversion of lactate. 3. The hormones glucagon, epinephrine, and insulin, can regulate blood glucose levels to protect the brain. For each one provide a short explanation as to whether it raises or lowers glucose how it does this, and indicate whether it is metabolic or catabolic.
Its principal function is to increase the concentration of glucose in the blood by speeding the glycogenolysis and gluconeogenesis in the liver.
Metabolic ketoacidosis is a common problem with diabetics, which is caused by which of the following? Excessive oxidation of fatty acids, leading to an accumulation of ketone bodies in the blood. Excessive oxidation of glucose, leading to an accumulation of ketone bodies in the blood. Excessive oxidation of proteins, leading to an accumulation of ammonia in the blood. Hyperglycemia.
Eating non-fibrous carbohydrates can cause a cycle of glucose dependenceand hunger represented by a glucose crash. Explain this situation showing the levels of insulin and blood glucose under this situation
In healthy adults, the concentration of glucose in blood is approximately80 to 110 milligrams per deciliter (mg/dl). After a carbohydrate-richmeal, however, the concentration may spike to 140 mg/dl. Describe thehormonal action that returns blood glucose to normal.
Lactose intolerance is caused by reduced production of the enzyme lactase. A variety of digestive system problems, such as celiac disease and Crohn’s disease) can also lower the production of lactase. If an individual produces low levels of the enzyme lactase, explain why they might be able to tolerate eating dairy products that contain lower levels of lactose (e.g., hard cheeses, feta cheese, and cottage cheese), but will not be able to tolerate foods with high levels of lactose (e.g., milk).
High amount of citrate decreases the activity of fructose 1,6-bisphosphatase. True or False

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