An antlanxlety medication, clorazepate, can bind to several receptors. These receptors differ In the amino acıd AApositlioned near the carboxyl group of clorazepate. All chemical groups are lonized according to pH 7. Which of thereceptors is likely to have the highest binding energy with clorazepate?Phesidechain - AAo-HTyrPheA. AA - SerB. AA - AspC. AA - GluD. AA - ArgE. AA - Gly

Arginine has highest binding energy with clorazepate. It is well-known that amino acids exist as…

Answered: An antlanxlety medication, clorazepate,…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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What is the significance of the blue regions of the following molecule? Me Me Me H oppo Me steroid skeleton O Me Me None of the answers O They are prone to metabolism, thus limiting the lifetime of the drug O They introduce a dipole moment to the molecule allowing the correct alignment of binding groups when the molecule binds to the binding site O They represent the skeleton of acetylcholine O They are polar groups that increase water solubility
The side chain of acetyl-L-lysine-OMe has a pKa=10.5 and its acid-dissociation reaction is shown below. see attachment for Question D.
A mutation of Lysine 82 (in the DPG-binding pocket) to Arginine in beta sub-unit will most likely result in Not enough information Higher than normal binding affinity to oxygen Lower than normal binding affinity to oxygen Normal binding to oxygen
The majority of amino acid residues found in the portion of a beta-barrel in contact with the transported solute are O hydrophobic O cyclic O hydrophilic O aromatic Previous Nort
Small molecules are used as inhibitors of protein action - as drugs. They most often do this by blocking the active site within the protein. Potential drugs can be screened computationally to determine if they are strongly bound to the protein. Figure 1 shows a possible conformation of a candidate drug molecule, 4-bromo-2- carboxymethylamide-pyrrole (abbreviation: BCMAP) at the active site of a protein (abbreviation: PR). Figure 2 shows the full protein structure whilst figure 3 shows a known inhibitor of the protein at the site, overlayed with another calculated conformer of BCMAP. (a) Explain what types of interactions, both intermolecular and intramolecular, that a molecular mechanics forcefield must be able to describe in order to be able to accurately determine the geometry of BCMAP in the protein. Identify which interactions will be the most important to describe accurately. Figure 1.4-bromo-2-carboxymethylamide-pyrrole (BCMAP) (C, N, O, and Br atoms in yellow, blue, red, and…
A3 KcsA K+ ion channel has their selectivity filer arranged as amino acid "TVGYG", so it can only binding with K+ ion, if this amino acid arrangement changed to "TVGDG", it can also select Na+ ion. why?
5. Anesthetic gases used in surgery are known to bind to the hemoglobin molecule in red blood cells. The diagram below illustrates O2 binding curves of normal human HbA in the presence of the anesthetic gas dichloromethane (DCM). O UNTREATED 100 Symbols: a Dсм 23 Torr • DCM 50 Torr x DCM I00 Torr o, 0 Torr DCM; О, 23 Torr DСМ Д, 50 Torr DСМ x, 100 Torr DCM. 80 60 40 (1 Torr = 1 mm Hg.) 20 The solutions were buffered to pH 7.4. 0.5 1.0 1.5 2.0 log p02 For the curves at 0 and 100 Torr of dichloromethane, draw their equivalent in the form of (a) (* Hill plots. Label the axes and indicate on both the plot above and the Hill plot where the value of the dissociation equilibrium constant Kd for O2 binding is defined for 0 and 100 Torr of dichloromethane Kd Hb(O2)n nO2 Hb + Be sure to label the axes, indicate the units on both axes, and make the Hill plot so that the values of Kd are equivalent to those on the saturation plot above. Indicate whether cooperativity, as indicated by the Hill…
Which of these peptides contain an amino acid with a side chain IMIDAZOLE? А. Охуtocin B. Vasopressin Based on amino acid composition, what is the overall charge of vasopressin? A. Negative C. Hard to tell D. Either A or B C. Neutral B. Positive D. Either A or B
What is the fractional occupancy of a protein binding site when the ligand concentration (L) =1mM and the ligand equilibrium binding constant at the binding site K10= 10microM. 0.01 B.0.1 C.0.91 D.0.99 none of the listed values
An emulsifying agent is a molecule that promotes the dispersion of one substance in another. Emulsifying agents areused to cause the interactions of hydrophobic and hydrophilic substances. They do so because their structures contain both hydrophobic and hydrophilic groups. Taurocholicacid is a bile salt, an emulsifying agent produced in the liverthat promotes fat digestion in the intestine. Its structure contains the amino acid taurine. Suggest a reason why taurinemakes taurocholic acid a better emulsifying agent thanglycocholic acid, a molecule in which glycine is substitutedfor taurine.
In the design of H2 antagonists, the polar guanidine group of compound A was proposed to interact with the antagonist binding region by two hydrogen bonds. This compelled researchers to derivatize compound B from compound A. HN EN Chain Extension Rigidification ZI compound A What drug design strategy has been used here? Simplification H₂N NH Substituent variation HN NH₂ HN NH N compound B
Which of the following is incorrect about the peptide Arg-Asp-Cys-Tyr-Gln-Arg-Glu? It has six peptide bonds b. It has a net charge of zero at pH 7 It has six charged groups at pH 7 d. None; all the other choices are correct a. C.

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